Tag: Coronavirus

1. In patients with confirmed SARS-CoV-2 infection within 7 days before or 30 days after surgery, significant mortality was observed, and perioperative pulmonary complications occurred in more than half the patients. Evidence Rating: 2 (Good) Current guidelines regarding the management of surgical patients during the SARS-CoV-2 pandemic are based solely on...
1. Findings from a cohort in Bergamo, Italy indicate a roughly 30-fold increase in the incidence of Kawasaki-like disease associated with the SARS-CoV-2 outbreak. 2. Pediatric patients diagnosed with Kawasaki-like disease post COVID-19 were more likely to have a more severe form of the disease, and had higher rates of...
1. Compared to patients who received remdesivir for 10 days, those in the 5-day group experienced no significant difference in either clinical outcomes or time to clinical improvement. 2. Although adverse events were slightly more frequent in the 10-day group, this effect may have been related to differences in baseline...
1. No association was found between angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker use and test-positivity for COVID-19. Evidence Rating Level: 2 (Good) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), gains entry into host cells by binding to the extracellular domain of transmembrane angiotensin-converting...
1. A total of 36.4% of the total sample of patients with SARS-CoV-2 infection demonstrated neurological manifestations of infection, with significantly greater likelihood found among those with severe infections. Evidence Rating Level: 2 (Good) While coronaviruses (CoVs) are known to impact the respiratory system they have systemic effects and can affect the...
Epidemiology, Clinical Course, and Outcomes of Critically Ill Adults With COVID-19 In New York City: A Prospective Cohort Study 1. COVID-19-positive adults were commonly found to have at least one comorbid condition, including hypertension and diabetes. 2. In-hospital mortality was independently associated with older age, chronic cardiac and pulmonary diseases, and...
1. In this study of 12 decedents with COVID-19, deep venous thrombosis was observed in over half of the study population. 2. Pulmonary embolism was the direct cause of death in a third of the patients autopsied. Evidence Rating Level: 4 (Below Average) Study Rundown: While the majority of people who develop...
1. Amongst the five examined classes of antihypertensive medications (ACE Inhibitors, ARBs, beta blockers, calcium-channel blockers, and thiazide diuretics), none were associated with a substantial increase in likelihood of COVID-19. Evidence Rating: 2 (Good) Infection of host cells by SARS-CoV-2 is mediated via an interaction with membrane-bound angiotensin-converting enzyme (ACE) 2,...
1. The interpretation of reverse transcriptase polymerase chain reaction (RT-PCR) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was shown to require caution particularly early in the course of infection. 2. RT-PCR results, alone, were shown not to be sufficient to rule out infection when the clinical suspicion was...
1. Following aggressive interventions across China since January 23, 2020, the confirmed case fatality risk in mainland China was 0.98%, five times smaller than that of Hubei, the epicenter of the COVID-19 spread.  2. Relaxing restrictions and allowing the instantaneous reproduction number to rise above 1, even if restrictions were...