Tag: Coronavirus

1. Patients with chronic obstructive pulmonary disease who were prescribed inhaled corticosteroids had an increased risk of COVID-19-related deaths compared to those on long-acting beta-agonist and long-acting muscarinic antagonist dual therapy. 2. Among asthma patients, a high-dose, but not low- or medium-dose, of inhaled corticosteroids was associated with an increased risk...
Section 4: Johnson & Johnson One of Top 5 COVID-19 Vaccine Finalists The Johnson & Johnson (J&J) Pharmaceutical Research and Development group has focused its COVID-19 vaccine efforts on a single-dose replication-defective human adenovirus 26 vector (Ad26.COV2.S).1,2,3 This vector deliver recombinant SARS-CoV-2 S protein genes to human cells. While no vaccines...
Section 3: Oxford/AstraZeneca Vaccine Shows Promise for Phase 3 Outcomes With many COVID-19 vaccine being studied and approved for emergency use, one important candidate is the chimpanzee adenovirus-vector (ChAdOx1 nCoV-19) expressing the SARS-CoV-2 spike protein.1 The University of Oxford developers of this vaccine have a partnership with AstraZeneca. This Phase 1/2...
Section 2: Moderna Vaccine Second to Receive Emergency Use Authorization The FDA Advisory Committee met on December 17, 2020, ultimately recommending the Moderna vaccine’s approval for emergency use in the prevention of COVID-19. After hospitals across the U.S. began to receive batches of the Pfizer/BioNTech vaccine, Moderna has become the...
Section 1: Pfizer/BioNTech Vaccine First to Receive Emergency Use Authorization to Prevent COVID-19 On December 11, 2020, the U.S. Food and Drug Administration (FDA) approved for emergency use the first vaccine to prevent coronavirus disease 2019 (COVID-19).1 This vaccine includes BNT162b2, a lipid nanoparticle-formulated, nucleoside-modified RNA and encodes a prefusion stabilized,...
1. Patients were significantly less likely to experience symptoms such as pain, dyspnea, and anxiety after utilization of home health care. 2. A substantial reduction was observed in the percentage of patients requiring assistance with each of the 9 activities of daily living that were examined. Evidence Rating Level: 2 (Good) Study...
1. In this open-label randomized controlled trial, with less than 50% adherence to recommendations, a recommendation for surgical masks did not confer statistically significant protection against SARS-CoV-2 infection compared to no recommendation. Evidence Rating Level: 4 (Below Average) Study Rundown: Community measures to reduce the transmission of SARS-CoV-2 are imperative as...
1. Presentation with shock in the setting of multisystem inflammatory syndrome in children (MIS-C) was associated with worse outcomes 2. Shorter duration of MIS-C symptoms prior to hospital admission was associated with poor outcomes Evidence Rating Level: 2 (Good) Study Rundown: MIS-C is a complication of SARS-CoV-2 that has led to severe...
1. There was a significant drop in administration of the MMR (measles, mumps, rubella) vaccine during the COVID-19 pandemic 2. Children who attended their preventative care visits were more likely to be vaccinated Evidence Rating Level: 2 (Good) Study Rundown: As the COVID-19 pandemic evolves, concern has been raised that vaccination rates...
1. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was shown to spread rapidly amongst the U.S.S Theodore Roosevelt crew due to close close-quarter conditions and asymptomatic infected crew members. 2. The Navy implemented procedures prior to deployment such as 14-day quarantine and viral testing for all members to reduce the...