Tag: Coronavirus

1. In a case series of febrile infants age 60 days or younger admitted to a New York City hospital, no patient had severe outcomes. 2. None of the infants required supplemental oxygen or had abnormal chest x-ray findings. Evidence Rating Level: 4 (Below Average) Study Rundown: Coronavirus disease 2019 (COVID-19) has...
1. Hydroxychloroquine use with or without azithromycin did not improve clinical outcomes at fifteen days when compared with standard of care in hospitalized patients with mild-to-moderate Covid-19. 2. A higher rate of side effects – including QT prolongation and elevated liver enzymes - was observed in patients taking hydroxychloroquine alone...
1. The mRNA-1273 SARS-CoV-2 (COVID-19) vaccine was shown to be safe and immunogenic amongst the 45 COVID-19 negative participants in this phase 1 clinical trial, when compared to serum convalescent plasma 2. Only patients in the highest 2 dosage groups experienced a severe febrile episode after the 2nd dose was...
1. Hematological tests including platelet count, prothrombin time (PT), D-dimer, and neutrophil-to-lymphocyte ratio can aid clinical decision making in managing patients with COVID-19, and predicting clinical severity and outcomes 2. The sepsis-induced coagulopathy scoring system may be used for early identification and management of patients with critical disease. Evidence Rating Level:...
1. The novel SARS-CoV-2 vaccine, ChAdOx1 nCoV-2, offered a reasonable safety profile with no serious adverse events in first phase 1/2 trial. 2. ChAdOx1 nCoV-2 showed neutralizing antibody responses against SARS-CoV-2 in the majority of patients. Evidence Rating Level: 1 (Excellent) Study Rundown: No vaccines have been approved for the prevention of...
1. In this double-blind, randomized trial, hydroxychloroquine did not reduce symptom severity in an adult, outpatient population. 2. More side effects, mainly gastrointestinal symptoms, were experienced by the patients in the treatment group. Evidence Rating Level: 1 (Excellent) Study Rundown: There are currently no effective oral therapies for the outpatient treatment of...
1. Old age, coronary heart disease, percentage of lymphocytes, procalcitonin and D-dimer were independent factors predictive of in-hospital COVID-19-related mortality; a predictive model combining these variables performed well in predicting poor prognosis among high-risk patients 2. Use of systemic corticosteroids for patients deemed low risk as per the COVID-19 Scoring...
1. In this case series, SARS-CoV-2 infection in children leading to multisystem inflammatory syndrome often required intensive care. 2. Of those who required intensive care, many required vasoactive support and inflammatory biomarkers were elevated in almost all patients. Evidence Rating Level: 3 (Average) Study Rundown: Coronavirus disease 2019 (COVID-19) has strained the...
1. Antibody testing to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was shown to provide diagnostic support for patients who tested negative by nucleic acid amplification test (NAAT) but remained clinically suspicious for the infection. 2. Antibody testing to SARS-CoV-2 was shown to contribute to the existing infection serology...
1. Virtual examination training and home-based diagnostics were vital to support providers’ decision-making capacities. 2. Current technology did not support multiparty videoconferencing and was not straightforward to use for providers. Evidence Rating Level: 5 (Poor) Study Rundown: Health systems have shifted to video visits to facilitate telehealth in order to observe social...