Tag: covid-19 infection

1. Methylprednisolone therapy in nonintubated patients with COVID-19 receiving high-flow oxygen therapy was associated with clinical benefit solely in patients with baseline serum ferritin levels in the upper tertile of values. 2. In contrast, for patients with ferritin in the lower and middle tertiles, no association with benefit was observed. Evidence...
1. The proportion of patients with one or more symptom sequelae significantly decreased from 6 months (68%) to 12 months (49%). 2. 88% of patients had returned to employment within 12 months of hospital discharge. Evidence Rating Level: 2 (Good) Study Rundown: Although COVID-19-related hospitalization is common, little is known about the long-term complications among...
1. The proportion of patients with one or more symptom sequelae significantly decreased from 6 months (68%) to 12 months (49%). 2. 88% of patients had returned to employment within 12 months of hospital discharge. Evidence Rating Level: 2 (Good) Study Rundown: Although COVID-19-related hospitalization is common, little is known about the...
1. Risk of acute myocardial infarction and ischemic stroke was increased during the first two weeks following a COVID-19 infection compared to the general population. 2. The risk of developing acute myocardial infarction and ischemic stroke decreased in weeks 3-4 following a COVID-19 infection compared to the first two weeks. Evidence...
1. The risk of SARS-CoV-2 infection was nearly 4-fold higher among health care workers working on COVID-19 inpatient wards compared to workers not in patient care, suggesting increased risk from nosocomial infection in this population. 2. Combined phylogenetic and epidemiological analyses found no patient-to-health care worker transmission but several health...
1. Older age, male sex, and pre-existing comorbidities were independent risk factors for developing complications following COVID-19 infection. 2. The most common complications included renal, complex respiratory, systemic, and cardiovascular. Evidence Rating Level: 2 (Good)  Study Rundown: Patients hospitalized with COVID-19 are likely to develop in-hospital complications which may worsen their prognosis....
1. Incidence of PCR-confirmed symptomatic COVID-19 cases was lower in the vaccine group compared with the placebo group (p<0.0001). 2. The majority of adverse events were mild and there was no vaccine-related mortality.  Evidence Rating Level: 1 (Excellent) Study Rundown: Inactivated vaccines offer a variety of benefits against transmission of severe acute...
1. Among patients hospitalized with severe COVID-19 and hyperinflammation, treatment using the anti-interleukin-1β antibody canakinumab, compared with placebo, did not significantly increase the likelihood of survival without invasive mechanical ventilation at day 29. 2. These findings for canakinumab vs placebo were also consistent for the secondary outcome of COVID-19-related mortality...
1. Health care assistants and nurses were at the highest risk of contracting SARS-CoV-2 among healthcare professionals early in the COVID-19 pandemic in Italy. 2. Healthcare workers employed in operational units that may result in prolonged exposure to SARS-CoV-2 patients, such as internal medicine and related subspecialties, were at higher...