Tag: covid-19 infection

1. The risk of SARS-CoV-2 infection was nearly 4-fold higher among health care workers working on COVID-19 inpatient wards compared to workers not in patient care, suggesting increased risk from nosocomial infection in this population. 2. Combined phylogenetic and epidemiological analyses found no patient-to-health care worker transmission but several health...

1. Older age, male sex, and pre-existing comorbidities were independent risk factors for developing complications following COVID-19 infection. 2. The most common complications included renal, complex respiratory, systemic, and cardiovascular. Evidence Rating Level: 2 (Good)  Study Rundown: Patients hospitalized with COVID-19 are likely to develop in-hospital complications which may worsen their prognosis....

1. Incidence of PCR-confirmed symptomatic COVID-19 cases was lower in the vaccine group compared with the placebo group (p<0.0001). 2. The majority of adverse events were mild and there was no vaccine-related mortality.  Evidence Rating Level: 1 (Excellent) Study Rundown: Inactivated vaccines offer a variety of benefits against transmission of severe acute...

1. Among patients hospitalized with severe COVID-19 and hyperinflammation, treatment using the anti-interleukin-1β antibody canakinumab, compared with placebo, did not significantly increase the likelihood of survival without invasive mechanical ventilation at day 29. 2. These findings for canakinumab vs placebo were also consistent for the secondary outcome of COVID-19-related mortality...

1. Health care assistants and nurses were at the highest risk of contracting SARS-CoV-2 among healthcare professionals early in the COVID-19 pandemic in Italy. 2. Healthcare workers employed in operational units that may result in prolonged exposure to SARS-CoV-2 patients, such as internal medicine and related subspecialties, were at higher...

1. In this epidemiological cohort study based out of Valencia, Spain, the neighborhood where the hospital and COVID-19 testing facility was situated correlated with a high number of total infectious connections and was potentially a major contributor to local spread. 2. These findings suggest that a more selective and strategic...

1. For patients hospitalized with COVID-19, both prophylactic- and treatment-dose anticoagulation were associated with lower in-hospital mortality compared with no anticoagulation. 2. However, given that only prophylactic anticoagulation was associated with mortality benefit at 60 days, anticoagulation prophylaxis should be considered in all patients hospitalized with COVID-19. Evidence Rating Level: 2...

1. In this cohort study, multisystem inflammatory syndrome in children was a rare but serious complication associated with SARS-CoV-2 infection. 2. The findings of increased incidence among younger people and those from ethnic minority groups emphasizes a need for further identification and risk stratification for multisystem inflammatory syndrome in children. Evidence...

1. A similar proportion of patients died within 28 days of randomization in both groups (high-titre convalescent plasma vs. usual care). 2. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days. Evidence Rating Level: 1 (Excellent) Study Rundown: Convalescent plasma is a...