Tag: diabetes
1. In a 15-year observational cohort study of type 2 diabetics treated with intensive compared to standard glucose control therapy the risk of major cardiovascular event or death was similar between both treatment groups.
2. There was no reported difference in health-related quality of life scores between the intensive and...
Glucagon-containing α-cells are important for regulating glucose homeostasis along with insulin-secreting β-cells. Glucagon receptor antagonists (GRAs) hold potential as antidiabetic therapies, but there is a concern that GRAs may cause α-cells to proliferate. While studies evaluating this have been carried out in rodents, these have been limited to young...
Amyotrophic Lateral Sclerosis versus Multifocal Motor Neuropathy: Utility of MR Neurography
Both multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis (ALS) affect the peripheral nervous system and present with palsies. Differentiating between these two diseases is important from a prognostic perspective, as MMN should be treated as early as possible...
Understanding the burden of health conditions in older adults in the U.S. is essential in addressing the healthcare demands of this patient population. This is of particular importance as the life expectancy in the U.S. continues to advance. In this retrospective cohort study, investigators analyzed data from 1998-2014 that...
In low and middle-income countries, the implementation of evidence-based therapies for cardiovascular disease, including the use of statins, antiplatelet therapy and anti-hypertensive medications, remains a challenge, despite high associated morbidity and mortality. In this cluster randomized controlled trial, 1619 patients with established atherosclerotic disease from 40 public and private...
Association of Racial Disparities With Access to Kidney Transplant After the Implementation of the New Kidney Allocation System
There are many reasons why a patient may be made inactive on the kidney transplant waiting list, including psychosocial or financial issues or medical comorbidities. This has important implications for a patient’s...
Induction of Labor at 41 Weeks Versus Expectant Management Until 42 Weeks (INDEX): Multicenter, Randomized Non-Inferiority Trial
It has been well established that pregnancy extending beyond 42 weeks is associated with higher rates of perinatal morbidity and mortality. However, there is variability in the current management of pregnancies extending beyond...
Association of Tourette Syndrome and Chronic Tic Disorder With Metabolic and Cardiovascular Disorders
Individuals with Tourette syndrome (TS) and other chronic tic disorders (CTD) are at an increased of developing cardiometabolic disorders, in part due to the adverse effects of pharmacologic treatment, including antipsychotics. In this cohort study, investigators analyzed...
1. A polygenic risk score for increased waist-to-hip ratio (WHR) was developed from over 200 risk loci.
2. Polygenic risk scores for higher WHR were significantly associated with higher risk of cardiometabolic disease, type 2 diabetes, and coronary disease, even when accounting for increased abdominal fat.
Evidence Rating Level: 2 (Good)
Study...
1. In this study, no significant differences were seen in the diabetes outcomes of patients managed by nurse practitioners (NPs) or physician assistants (PAs) compared to patients managed by physician primary care providers (PCPs).
2. The results of the study indicated that chronic illnesses could be effectively managed by any...