Tag: diabetes

1. In this study, patients with high-deductible health care plans were more likely to delay seeking care for the treatment of macrovascular complications of diabetes. 2. Patients with high-deductible health care plans, compared to those with low-deductible health care plans, were also less likely to undergo procedure-based treatments for diabetes...

Glucagon-like peptide-1 (GLP-1) potentiates the release of insulin from pancreatic beta cells in a glucose-dependent manner. While pharmacologic studies have shown that GLP-1 delays gastric emptying, reduces appetite, decreases food intake, and therefore, contributes to improved glucose homeostasis and bodyweight, some patients fail to achieve glycemic and bodyweight targets....

There is a strong relationship between body weight and the risk of developing diabetes. Lorcaserin is a selective serotonin 2C receptor agonist that suppresses appetite, and has been shown to sustain weight loss. This randomized double-blind placebo-controlled trial aimed to evaluate the long-term effects of lorcaserin on diabetes prevention...

Effect of Early Surgery vs Physical Therapy on Knee Function Among Patients With Nonobstructive Meniscal Tears: The ESCAPE Randomized Clinical Trial Despite multiple studies indicating that arthroscopic partial meniscectomy (APM) is not more effective than physical therapy (PT), this procedure continues to be performed widely in patients with meniscal tears....

1. WHO guidelines recommend selecting sulfonylureas as the single best second-line agent for Type 2 Diabetes Mellitus (T2DM) patients. 2. Authors of a commentary on the WHO guidelines highlighted the prioritization of cost in the clinical decision-making. Evidence Rating Level: 2 (Good) Study Rundown: T2DM remains an increasing health concern for patients,...

1. Patients who received gastric bypass surgery had lower rates of diabetic neuropathy at follow up that remained stable throughout the study. 2. Bariatric surgery was associated with lower rates of diabetic retinopathy compared to usual care. Evidence Rating Level: 2 (Good) Study Rundown: Bariatric surgery has been shown to have significant...

Change in Overweight from Childhood to Early Adulthood and Risk of Type 2 Diabetes High body mass index (BMI) in children is associated with an increased risk of type 2 diabetes in adulthood. This study aimed to investigate whether achieving remission from overweight prior to adulthood mitigates this increased risk....

1. A device for islet transplantation for type 1 diabetes was designed and demonstrated to be safe and retrievable in animal models. 2. When tested in mice and dogs, this device successfully reduced glucose levels. Evidence Rating Level: 2 (Good) Study Rundown: Type 1 diabetes is an autoimmune condition that attacks pancreatic...

1. In this 30-year prospective cohort study, self-reported duration of lactation in women of childbearing age was associated with a lower risk of development of diabetes. 2. The association between lactation and lower diabetes risk remained consistent after accounting for important cofactors including gestational diabetes, baseline metabolic profile, and race. Evidence...

1. GHRH and GHRH receptor levels are decreased in diabetic rats and humans. 2. Administration of GHRH agonists to diabetic rats reversed signs of diabetic retinopathy. Evidence Rating Level: 2 (Good) Study Rundown: Diabetic retinopathy is the main cause of blindness in the Western world. However, effective treatment for this condition remains...