Tag: Duchenne muscular dystrophy

1. Mutations in the gene encoding dystrophin, a large scaffolding protein that supports muscle cell structure, result in Duchenne muscular dystrophy (DMD). 2. A gene editing strategy to correct the dystrophin reading frame in a canine model of DMD is shown to partially restore dystrophin protein expression in skeletal and...
1. Dietary supplementation with nicotinamide riboside (NR), a form of vitamin B3 that acts as a precursor to nicotinamide adenine dinucleotide (NAD+), increased levels of NAD+ and reduced deterioration of muscle structure in mouse models of Duchenne muscular dystrophy (DMD). 2. Concomitantly, NR treatment led to improved mitochondrial energetics...