Tag: Gastroenterology

1. The early introduction of the gluten into the diet of infants was associated with a lower incidence of celiac disease at age 3 years. Evidence Level Rating: 2 (Good) The Enquiring About Tolerance (EAT) Study, a randomized controlled trial published in 2016, assessed whether introducing allergenic foods to infants’ diet...
1. Anemia increased the risk of development of Crohn’s disease, inversely to hemoglobin concentration 2. Anemia was not associated with an increased risk of ulcerative colitis. Evidence Rating Level: 2 (Good) Though inflammatory bowel disease (IBD) can lead to anemia, whether anemia may be a surrogate marker for the early detection of...
1. Among patients managed without surgery, the conditional recurrence-free survival of diverticulitis increased with each year survived recurrence-free. 2. Lower age and higher comorbidity burden were both associated with an increased risk of recurrence. Evidence Level Rating: 2 (Good) Sigmoid diverticulitis is a very common gastrointestinal condition, and although the rate of...
Click to read the study in PlosONE Image: PD ©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the...
1. Increased expression of the protein hemopexin in stroma of patients with pancreatic ductal adenocarcinoma may be associated with lymph node metastasis. Evidence Rating Level: 2 (Good) Pancreatic ductal adenocarcinoma (PDAC) has a 5-year survival rate of 7% and patients with lymph node metastases (≥4) have a 25% lower 5-year survival...
Click to read the study in PlosONE Image: PD ©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the...
1. The gut virome among patients with severe NAFLD was found to be different than those with milder NAFLD. #2. Adding viral diversity to clinical models used to predict NAFLD severity significantly increased diagnostic accuracy. Evidence Level Rating: 2 (Good) Non-alcoholic fatty liver disease (NAFLD) affects approximately 25% of the world’s...
1. Researchers used whole-exome sequencing to define the novel CHAPLE syndrome, characterized by a homozygous CD55 mutation with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy. 2. Eculizumab, an antibody against complement component C5a, reduced C5a levels in T-cell cultures from patients with CHAPLE syndrome and may be a potential...
1. Increased in-hospital time to surgery was not associated with an increased risk of appendix rupture among adults treated with appendectomy. 2. Factors that increased the risk of perforation included male gender, lack of insurance, and >3 comorbid conditions. Evidence Rating Level: 2 (Good) Study Rundown: Previous reports have demonstrated conflicting results...
Image: PD 1. Meta-analysis of trials involving eradication of Helicobacter pylori (H. pylori) in asymptomatic individuals showed significant decrease in gastric cancer incidence compared to placebo. Evidence Rating Level: 2 (Good) Study Rundown: Infection from H. pylori has been strongly associated with an increased incidence of gastric cancer. However, the use and...