Tag: losartan

1. In this randomized, controlled trial, patients without cardiovascular disease randomized to receive a polypill containing atorvastatin, amlodipine, losartan, and hydrochlorothiazide experienced greater reductions in systolic blood pressure and low-density lipoprotein (LDL) cholesterol over 12 months compared to patients who received usual-care. 2. Polypill patients reported increased rates of myalgia,...
1. In this randomized, controlled trial, patients without cardiovascular disease randomized to receive a polypill containing atorvastatin, amlodipine, losartan, and hydrochlorothiazide experienced greater reductions in systolic blood pressure and low-density lipoprotein (LDL) cholesterol over 12 months compared to patients who received usual-care. 2. Polypill patients reported increased rates of myalgia,...
Classics Series, Landmark Trials in Medicine
Image: PD 1. In patients with type II diabetes and nephropathy, losartan at a dose of 50-100 mg daily significantly reduced the risk of developing end-stage renal disease compared to placebo. 2. While losartan also significantly reduced the degree of proteinuria in these patients, it did not significantly reduce mortality when...
Image: PD  1. From a systematic review of the literature, there is insufficient evidence to suggest a link between statins and cognitive dysfunction. Evidence Rating Level: 1 (Excellent)  Study Rundown:  Although the most common adverse sequela of statin use is myopathy, the FDA has recently added cognitive defects, such as memory loss...