Tag: malaria

1. No overall significant difference was found in infant malaria incidence between mothers taking intermittent preventive treatment (IPTp) with sulfadoxine-pyrimethamine versus dihydroartemisinin-piperaquine. 2. Dihydroartemisinin-piperaquine (DP) was associated with lower incidence of malaria infant males compared to traditional sulfadoxine-pyrimethamine (SP) use in the first year of life. Evidence Rating Level: 2 (Good) To...
Plasmodium vivax (P. vivax) malaria is a major cause of morbidity and mortality throughout the world. Primaquine, an 8-aminoquinoline, is the only widely available drug that prevents relapse, but its use is limited by the risk of acute hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency in addition to...
Association of Immune Marker Changes With Progression of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma Multiple myeloma often develops from the precursor condition monoclonal gammopathy of undetermined significance (MGUS), which is detectable in peripheral blood. Similarly, the light-chain subtype of multiple myeloma is preceded by light-chain MGUS. Clinical guidelines...
1. After initial chloroquine treatment, P. vivax malaria infected patients treated with tafenoquine had significantly lower rates of P. vivax infection at 6 months compared to patients given placebo. 2. Mean hemoglobin levels were mildly reduced in the tafenoquine group but returned to baseline after treatment. Evidence Rating Level: 1 (Excellent)       Study Rundown: P. vivax, one of the...
1. After initial chloroquine treatment, P. vivax malaria infected patients treated with tafenoquine had significantly lower rates of P. vivax infection at 6 months compared to patients given placebo. 2. Mean hemoglobin levels were mildly reduced in the tafenoquine group but returned to baseline after treatment. Evidence Rating Level: 1 (Excellent)       Study...
1. RTS,SA/S01 malaria vaccine had significantly higher efficacy rates compared to placebo within the first year of administration. 2. Over the course of seven years, RTS,SA/S01 malaria vaccine efficacy rates waned significantly. Evidence Rating Level: 1 (Excellent) Study Rundown: Malaria continues to be a significant public health concern, with over an estimated...
  1. All four artemisinin-based treatment groups had cure rates of over 94%. Artemether-lumefantrine was statistically less efficacious than the other three regimens however was only less efficacious by 2%. 2. Rates of serious adverse events were not statistically significant across the four treatment groups. Evidence Rating Level: 1 (Excellent) Study Rundown:...
Randomized Trial of Stent versus Surgery for Asymptomatic Carotid Stenosis Extra-cranial carotid artery disease is responsible for 20% of strokes. Literature suggests that carotid artery stenting is an effective alternative to endarterectomy in high risk surgical patients. The ACT I study prospective multicenter trial involving 1453 patients with severe atherosclerotic...
Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine The RTS,S/AS01 vaccine is a monovalent recombinant protein vaccine that targets a fragment of the circumsporozoite protein parasite antigen for protection against Plasmodium falciparum malaria infection. Malaria has proven to be challenging for vaccine-development efforts around the world. The purpose...
1. Reduction in maternal antimalarial IgG levels was associated with decreased prevalence of malaria over a 10-year period in pregnant women.  2. Decrease in the prevalence of malaria over 10-year period in pregnant women was associated with increasing maternal parasite densities and larger adverse effect of infection on both mother...