Tag: menopause

1. In this analysis of two randomized controlled trials, hormone replacement therapy (HRT) was not associated with a change in all-cause mortality among post-menopausal women. 2. No change in cancer or cardiovascular mortality was associated with HRT. Evidence Rating Level: 1 (Excellent) Study Rundown: The Women’s Health Initiative Hormone Replacement Therapy (HRT)...
1. This systematic review found that there was an association between overall phytoestrogen use and the degree of hot flashes and vaginal dryness in menopausal women. 2. There was no association between phytoestrogen use and night sweat symptoms, nor were there any significant associations between menopausal symptoms and the use...
1. Paroxetine use was associated with decreased frequency of hot flashes and lower composite vasomotor symptom (VMS) severity score. 2. Women randomized to receive paroxetine were more likely to experience nausea and dizziness than those randomized to placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: Hot flashes, which may include symptoms of...
1. From this randomized, partially-blinded, sham-controlled trial, Chinese medicine acupuncture was not superior to sham (i.e., non-insertive) acupuncture to treat menopausal hot flashes in women with kidney yin deficiency. 2. Patients in both the treatment and sham arms of the study experienced a decrease in hot flash symptoms at the...
1. Women with a history of perimenopausal depression experienced an increase in severity of depression after estrogen withdrawal. 2. These women reported avoidance of socialization, sleep disturbances, and decreased motivation following discontinuation of hormone therapy. Evidence Rating Level: 1 (Excellent)       Study Rundown: Menopause denotes the permanent cessation of menstruation and is diagnosed...
1. Postmenopausal women’s cervicovaginal fluid had lower anti-HIV-1 activity than premenopausal women. 2. Timing of menstrual cycle and hormonal contraception were not associated with differences in activity against HSV or HIV. Evidence Rating Level: 3 (Average)     Study Rundown: Among older individuals, lack of safe sex education, delayed or absent screening...
1. In this meta-analysis of postmenopausal women with ovarian cancer, the risk of ovarian cancer was strongly associated with recent (<5 years) or current use of hormone replacement therapy but decreased with increasing time after cessation of therapy. 2. Applying the results to ovarian cancer incidence and death rates in...
1. A retrospective review of data from the Women’s Health Initiative found that both postmenopausal weight gain and weight loss were associated with an increased risk of fractures. 2. Although both intentional and unintentional weight loss increased fracture risk, the pattern of fractures in postmenopausal women differed by intentionality of...
1. After adjusting for age, smoking history and parity, there was no significant association between type I diabetes and early menopause. Evidence Rating Level: 2 (Good)   Study Rundown: The average age of menopause, which is defined as 12 months of amenorrhea, is 51.2 years among American women, although age at...