Tag: Prophylaxis

1. In this double-blind, randomized trial, hydroxychloroquine did not reduce symptom severity in an adult, outpatient population. 2. More side effects, mainly gastrointestinal symptoms, were experienced by the patients in the treatment group. Evidence Rating Level: 1 (Excellent) Study Rundown: There are currently no effective oral therapies for the outpatient treatment of...
1. Maraviroc pre-exposure prophylaxis regimens were observed to be safe and well tolerated in patients. 2. No new HIV infections occurred during the course of the 48-week study. Evidence Rating Level: 1 (Excellent) Study Rundown: HIV prevention is an important area of public health, as over 2 million new HIV infections occur...
1. For patients who received pre-exposure prophylaxis delivered through sexual health clinics in the United States, the adherence rate was 80.0% to 85.6%, and HIV incidence was low. 2. Improved adherence was associated with patients who had stable housing, reported more at-risk sexual activities, and those who had better initial...
Image: PD 1. High-dose prophylaxis for severe hemophilia increases total cost of care.  2. Compared to intermediate-doses, high-dose prophylaxis reduces bleeding and hemophilic arthropathy, but results in equal quality of life.  Evidence Rating Level: 2 (Good) Study Rundown: Though relatively rare, patients with severe hemophilia are at risk for spontaneous and trauma-related bleeding leading to...
Image: PD 1. Short-term zinc prophylaxis in infants is associated with decreased morbidity from diarrheal episodes.  2. In those infants receiving zinc supplementation, there was a decrease in incidence and duration of diarrheal episodes, and total number of days suffering from diarrhea during the 5 months following supplementation.  Evidence Rating Level:...
In this section, we will highlight the some of the key high-impact studies, updates, and analyses published in the past week. ADVANCE III Trial: Effect of Long-Detection Interval vs Standard-Detection Interval for Implantable Cardioverter-Defibrillators on Antitachycardia Pacing and Shock Delivery An international RCT suggests that implantable cardioverter-defibrillators (ICDs) programmed to respond...