Tag: sertraline

The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, placebo-controlled randomised trial 1. Selective serotonin reuptake inhibitors (SSRIs) are not associated with significant short-term reductions in depressive symptoms in the primary care setting, but reduce short-term anxiety and improve...
1.  In this randomized controlled trial, patients with Major depressive disorder with psychotic features who were stable on olanzapine and sertraline showed higher relapse upon discontinuation of olanzapine than those who remained on both drugs over 36 weeks. 2. Patients who remained on both drugs had more weight gain but...
1.  In this randomized controlled trial, patients with Major depressive disorder with psychotic features who were stable on olanzapine and sertraline showed higher relapse upon discontinuation of olanzapine than those who remained on both drugs over 36 weeks. 2. Patients who remained on both drugs had more weight gain but...
Effect of Sertraline on Depressive Symptoms in Patients With Chronic Kidney Disease Without Dialysis Dependence Major depressive disorder (MDD) affects a significant number of patients with chronic kidney disease (CKD). Due to safety concerns, these patients have been largely omitted from clinical trials evaluating the efficacy of commonly used antidepressants....
Targeting Mutant BRAF in Relapsed or Refractory Hairy-Cell Leukemia BRAF V600E has been identified as the genetic lesion responsible for the development of hairy-cell leukemia.  In this study, researchers conducted two phase-2, single-group, multicenter trials looking at the effectiveness and safety of oral vemurafenib (a BRAF inhibitor) in patients with...
Classics Series, Landmark Trials in Medicine
1. In cases where citalopram fails or cannot be tolerated, approximately 1 in 4 patients will experience remission of their depression symptoms by switching to sustained-release buproprion, sertraline, or extended-release venlafaxine. Original Date of Publication: March 2006 The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trials explored the management of patients...