Tag: troponin

1. In this randomized controlled trial, heart failure with preserved ejection fraction (HFpEF) patients did not have improved exercise capacity with neladenoson versus placebo. 2. There were no changes in activity intensity, NT-proBNP level, high-sensitivity troponin T level, or quality of life with neladenoson. Evidence Rating Level: 1 (Excellent) Study Rundown: Heart failure...

1. In this randomized controlled trial, heart failure with preserved ejection fraction (HFpEF) patients did not have improved exercise capacity with neladenoson versus placebo. 2. There were no changes in activity intensity, NT-proBNP level, high-sensitivity troponin T level, or quality of life with neladenoson. Evidence Rating Level: 1 (Excellent) Study Rundown: Heart...

1. Among patients admitted for suspected acute coronary syndrome but discharged without a specific diagnosis, higher cardiac troponin levels were associated with elevated all-cause and cardiovascular mortality. Evidence Rating Level: 2 (Good) Study Rundown: Cardiac troponin is one of the most commonly ordered lab tests in acute care facilities, and there...

The following study summary is an excerpt from the book 2 Minute Medicine’s The Classics in Radiology: Summaries of Clinically Relevant & Recent Landmark Studies, 1e (The Classics Series). 1. In patients presenting with chest pain and a low to intermediate risk of acute coronary syndrome (ACS), computed tomographic coronary angiography...

1. In this meta-analysis, researchers found that a high-sensitivity cardiac troponin T (hs-cTnT) assay along with a nonischemic electrocardiogram (ECG) could be used to classify 30.6% of 9241 adults arriving at the emergency department (ED) for possible cardiac-related chest pain as low-risk for acute myocardial infarction (AMI). 2. This suggests...

1. In this prospective cohort study, a low serum troponin concentration under 5ng/L had a negative predictive value of 99.6% for the primary outcome of index myocardial infarction (MI). 2. At 1 year, patients with serum troponin concentrations of less than 5ng/L were at a lower risk of MI...

Acetaminophen for Fever in Critically Ill Patients with Suspected Infection Acetaminophen is a commonly used anti-pyretic in patients admitted to the hospital, including those admitted to an intensive care unit (ICU) with potential infection/sepsis.  The benefits and potential risks of treatment of fever in ICU patients have been debated for...

1. Patients with abnormal troponin T levels had a significantly higher rate of death from all causes at the 5-year follow up. 2. Early revascularization of patients with elevated levels of troponin T did not lower the risk of death. Evidence Rating Level: 1 (Excellent)       Study Rundown: Troponin T...

Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer Cancer immunotherapy seeks to up regulate immune activators and down regulate immune suppressing agents to induce the body's own immune system to confront malignancy. Nivolumab, a monoclonal antibody to PD1 (immune checkpoint inhibitor), has been tried in highly immunogenic malignancies such...

In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. High Sensitivity Cardiac Troponin and Under-diagnosis of Myocardial Infarction in Women: Prospective Cohort Study The reference limit for cardiac troponin levels in defining myocardial infarction (MI) is currently the same for men...