• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Venetoclax demonstrates antitumor activity in relapsed CLL

byNeil D'SouzaandShaidah Deghan, MSc. MD
December 10, 2015
in Chronic Disease, Oncology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

 

1. In this phase I trial, gradual dose escalation with selective BCL2 inhibitor, venetoclax, showed a manageable safety profile and significant antitumor activity for treatment of relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic leukemia (SLL).

2. Venetoclax was safe and active at all dose levels, with no maximum tolerated dose identified.

Evidence Rating Level: 2 (Good)

Study Rundown: Patients with relapsed or refractory CLL have elevated expression of anti-apoptotic BCL2 proteins, resulting in accumulation of clonal cells. Ventoclax is a highly selective and potent inhibitor of BCL2, inducing apoptosis in vitro and in vivo models. Based on these models, this first-in-human phase I trial in patients with relapsed or refractory CLL or SLL aimed to establish a safety profile, pharmacokinetic profile, maximum tolerated dose, and dosing schedule for a phase II trial. The majority of patients had multiple prior treatments and poor prognostic factors. Results indicated venetoclax was active at all doses with associated patient response in the majority of cases, but no maximum tolerated dose was identified. Clinical tumor lysis syndrome occurred in a small number of patients in the dose escalation cohort, but not in the dose expansion cohort. Minor toxicities included nausea, diarrhea, upper respiratory tract infection and neutropenia. Limitations of this study include the small sample size, and lack of blinding and randomization, making results difficult to generalize. However, given the challenge in managing relapsing and recurrent CLL, venetoclax represents a promising treatment option for such patients, and its toxicity profile is manageable.

Click to read the study, published today in NEJM

Relevant Reading: Substantial susceptibility of Chronic Lymphocytic Leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

RELATED REPORTS

#VisualAbstract: Venetoclax consolidation after fixed-duration venetoclax plus obinutuzumab treatment does not show added activity in chronic lymphocytic leukaemia

#VisualAbstract Venetoclax with dose-adjusted EPOCH-R may be a promising combination therapy for aggressive B-cell lymphoma

#VisualAbstract OAsIS: Ibrutinib, obinutuzumab, and venetoclax was well-tolerated and showed high response rates in both untreated and relapsed mantle cell lymphoma

In-Depth [prospective cohort]: This phase I dose-escalation study of oral venetoclax, a BCL2 anti-apoptotic inhibitor, aimed to assess its safety, pharmacokinetic profile and efficacy in patients with relapsed or refractory CLL or SLL. In the dose escalation cohort, there were 8 dose groups (150-1200mg) spread across 56 patient participants. In the dose expansion group, a weekly dose increases were given to 60 patients.

There were a total of 116 patients, 89% of whom had poor prognostic clinical or genetic features. Tumour lysis syndrome occurred in 18% of patients in the dose escalation cohort. In the dose expansion cohort, 1 patient had laboratory evidence of tumor lysis syndrome, but none had clinical symptoms. Other side effects included: mild diarrhea (52%), upper respiratory tract infection (46%), nausea (47%) and neutropenia (41%; grade 3/4). The pooled overall response rate for the 116 patient participants was 79%, with a 20% complete response rate.  In patients with a 17p CLL deletion, the response rate was 71%, with a 16% complete response rate.  In the dose escalation cohort, the median duration of progression-free survival was 25 months (95% CI, 17-30). No similar data was obtained in the dose expansion cohort due to short follow up (median follow up duration, 17 months; range <1-26).

Image: PD

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: venetoclax
Previous Post

High school cheerleading injury rates lower than other sports

Next Post

Mass administration of ivermectin may decrease prevalence of scabies and impetigo

RelatedReports

#VisualAbstract: Venetoclax consolidation after fixed-duration venetoclax plus obinutuzumab treatment does not show added activity in chronic lymphocytic leukaemia
StudyGraphics

#VisualAbstract: Venetoclax consolidation after fixed-duration venetoclax plus obinutuzumab treatment does not show added activity in chronic lymphocytic leukaemia

March 24, 2022
#VisualAbstract Venetoclax with dose-adjusted EPOCH-R may be a promising combination therapy for aggressive B-cell lymphoma
StudyGraphics

#VisualAbstract Venetoclax with dose-adjusted EPOCH-R may be a promising combination therapy for aggressive B-cell lymphoma

October 21, 2021
#VisualAbstract OAsIS: Ibrutinib, obinutuzumab, and venetoclax was well-tolerated and showed high response rates in both untreated and relapsed mantle cell lymphoma
StudyGraphics

#VisualAbstract OAsIS: Ibrutinib, obinutuzumab, and venetoclax was well-tolerated and showed high response rates in both untreated and relapsed mantle cell lymphoma

March 5, 2021
#VisualAbstract CONTRALTO Phase II: Venetoclax-Rituximab With or Without Bendamustine VS Bendamustine-Rituximab in Relapsed/Refractory Follicular Lymphoma
StudyGraphics

#VisualAbstract CONTRALTO Phase II: Venetoclax-Rituximab With or Without Bendamustine VS Bendamustine-Rituximab in Relapsed/Refractory Follicular Lymphoma

December 11, 2020
Next Post
Mass administration of ivermectin may decrease prevalence of scabies and impetigo

Mass administration of ivermectin may decrease prevalence of scabies and impetigo

Pre-operative magnetic resonance imaging may not improve contralateral breast cancer detection

Pre-operative magnetic resonance imaging may not improve contralateral breast cancer detection

Increased risk of stillbirth recurrence after a previous stillbirth

Gains in life expectancy linked with gains in health expectancy in old age

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Plant-based diets may be associated with lower risk of aggressive prostate cancer
  • #VisualAbstract: Adagrasib provides antitumour activity against KRAS G12C mutant metastatic colorectal cancer both as monotherapy and in combination with cetuximab
  • Chronic obstructive pulmonary disease associated with worse postoperative outcomes
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options