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Home StudyGraphics

#VisualAbstract: Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients

byStudy Graphics | C.WuandConstance Wu
August 22, 2020
in StudyGraphics
Reading Time: 2 mins read
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#VisualAbstract: Transcatheter aortic valve implantation is associated with reduced rate of structural valve deterioration compared to surgery

1. This randomized control trial compared post-surgical outcomes between transcatheter aortic-valve replacement (TAVR) with balloon-expandable valves or surgical valve replacement in low- risk surgical patients, finding that patients randomized to receive TAVR had significantly lower rates of composite death, stroke or rehospitalization after one year.

2. Patients randomized to the TAVR group also had lower rates of new-onset atrial fibrillation and had shorter hospital stays.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Transcatheter aortic-valve replacement (TAVR) is a minimally invasive procedure approved for the treatment of severe aortic stenosis. When it was first introduced, TAVR was initially regarded as an alternative therapy for patients who were unable to undergo open heart surgery and surgical valve replacement. However, the clinical guidelines for TAVR have since been expanded after clinical trials showed that the procedure was noninferior, if not superior, to surgical intervention among patients at intermediate or high surgical risk. This current analysis further explored the efficacy of TAVR versus surgical aortic valve replacement (SAVR) among patients with low surgical risk. In the Placement of Aortic Transcatheter Valves (PARTNER) 3 trial, researchers studied comparative post-surgical outcomes including composite rates of death, stroke and rehospitalization between patients randomized to undergo TAVR with balloon-expandable valves versus those randomized to receive open heart surgery with SAVR. Overall, researchers found that the TAVR group had significantly lower composite rates of death, stroke or rehospitalization after one year. The TAVR group also had lower rates of new-onset atrial fibrillation, and shorter hospitalization stays. It was also noted that those who underwent TAVR had more rapid improvement in their NYHA class score, 6-minute walk tests and Kansas City Cardiomyopathy Questionnaire (KCCQ) score post procedure. While these results were only studied for a period of one year and longer-term follow up is needed, this study could expand clinical guidelines for TAVR use even further in the management of severe aortic stenosis.

Click to read the study in NEJM

©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc

Tags: aortic stenosiscardiovascular diseaseTranscatheter aortic valve replacement (TAVR)
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