• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home StudyGraphics

#VisualAbstract: Efficacy and Safety of Lanabecestat for Treatment of Early and Mild Alzheimer Disease

byConstance Wu
December 21, 2019
in StudyGraphics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

RELATED REPORTS

#VisualAbstract: Anti-tau antibody Semorinemab not shown to slow clinical progression of Alzheimer’s disease

Anti-tau antibody Semorinemab not shown to slow clinical progression of Alzheimer’s disease

Rare APOE missense variants V236E and R251G associated with substantial reduction in risk of Alzheimer disease

1. While well-tolerated in early and mild Alzheimer’s disease, the BACE1 inhibitor lanabecestat was generally ineffective in slowing cognitive and functional decline.

Evidence Rating Level: 1 (Excellent)

Amyloid plaques and neurofibrillary tangles are defining pathological characteristics of Alzheimer’s disease (AD). Inhibitors of the beta-site APP-cleaving enzyme 1 (BACE1) may reduce the formation of Aβ peptides. Therefore, the objective of the AMARNATH and DAYBREAK-ALZ randomized, global multicenter, double-blind, placebo-controlled trials was to assess the effectiveness and safety of the BACE1 inhibitor lanabecestat in slowing cognitive deterioration and disease progression compared to placebo in early and mild AD. AMARANTH occurred over the course of 104 weeks, and included individuals across the spectrum from AD-related mild cognitive impairment (MCI) to mild AD dementia. DAYBREAK-ALZ  similarly included mild AD dementia patients, with a 78-week placebo-controlled period, and a subsequent 78-week period during which all participants transitioned to lanabecestat. Participants were stratified by cognitive status at baseline and equally randomized to once-daily doses of 20mg lanabecestat, 50mg lanabecestat, or placebo. Evaluative tools to determine impairment were the 13-item Alzheimer Disease Assessment Scale-cognitive subscale (ADAS-Cog13), Alzheimer’s Disease Cooperative Study-Instrumental Activities of Daily Living Inventory (ADCS-iADL), Functional Activities Questionnaire (FAQ), Integrated Alzheimer’s Disease Rating Scale (iADRS), Clinical Dementia Rating-sum of boxes (CDR-SB), Neuropsychiatric Inventory (NPI), and Mini-Mental Status Examination (MMSE). Reported adverse events, weight and vital signs, laboratory tests, physical examination (e.g., neurological/imaging, dermatological), and suicidality were also assessed throughout the studies. Lastly, biomarkers related to amyloid markers (CSF Aβ-42 and Aβ-40), hippocampal volume (MRI), and amyloid burden (florbetapir PET) were evaluated. The primary outcome was change from baseline in the ADAS-Cog13. A total of 2,218 participants were eligible for AMARANTH (mean [SD] age = 71.3 [7.1] years) and 1,722 were eligible for DAYBREAK-ALZ (mean [SD] age = 72.3 [7.0] years). Baseline cognitive and functional scores were similar across studies in spite of their disease status differences, though all scored at least one SD below the population mean for MCI and three SDs below for mild AD. Both studies were discontinued early for futility, which likely impacted results. Incidence of deaths were similar across treatment groups in both of these studies; study discontinuation due to adverse events was highest in the 50mg lanabecestat group (difference 2.5%). Specifically,the 50mg lanabecestat group experienced increased hair hypopigmentation, and both lanabecestat groups resulted in a higher number of emergent psychiatric events. Regarding cognitive and functional capacities during the studies’ durations, lanabecestat did not slow decline compared to placebo. The 20mg and 50mg treatment arms in AMARANTH showed significantly greater hippocampal volume loss (-0.52% and -0.48%, respectively) compared to placebo, but these findings were not observed in DAYBREAK-ALZ. However, no significant differences were found in cognitive measures and, in certain cases, worsening of function was noted in lanabecestat groups without distinguishable differences between the two studies. Despite early termination, these large studies suggest that the BACE1 inhibitor lanabecestat does not appear to serve as a disease-modifying agent under current conditions.

Click to read the study in JAMA Neurology

©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: Alzheimer’s diseaseamyloid plaqueBACE-1 inhibitorlanabecestat
Previous Post

Association Between Change in Circulating Progenitor Cells During Exercise Stress and Risk of Adverse Cardiovascular Events in Patients With Coronary Artery Disease

Next Post

Maternal diabetes during pregnancy and early onset of cardiovascular disease in offspring

RelatedReports

#VisualAbstract: Varenicline improves successful smoking cessation amongst African American daily smokers: KIS-IV Trial
StudyGraphics

#VisualAbstract: Anti-tau antibody Semorinemab not shown to slow clinical progression of Alzheimer’s disease

June 29, 2022
Genetic risk assessment for Alzheimer’s disease does not increase anxiety, depression or stress
Chronic Disease

Anti-tau antibody Semorinemab not shown to slow clinical progression of Alzheimer’s disease

June 17, 2022
Amyloid pathology may be detected decades prior to Alzheimer’s diagnosis
Chronic Disease

Rare APOE missense variants V236E and R251G associated with substantial reduction in risk of Alzheimer disease

June 2, 2022
Genetic risk assessment for Alzheimer’s disease does not increase anxiety, depression or stress
Chronic Disease

Alzheimer disease in individuals with Down syndrome has similar variability in age of onset and mortality rate as autosomal dominant forms

May 26, 2022
Next Post
Maternal vaccination during pregnancy not associated with infant hospitalization, mortality

Maternal diabetes during pregnancy and early onset of cardiovascular disease in offspring

Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X)

Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X)

Obeticholic acid for the treatment of non-alcoholic steatohepatitis

Obeticholic acid for the treatment of non-alcoholic steatohepatitis

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Cognitive behavioral therapy efficacious for treatment of comorbid posttraumatic headache and posttraumatic stress disorder symptoms among US veterans
  • Sickle cell trait associated with preexisting kidney comorbidities and increased COVID-19 mortality
  • Adding atezolizumab to standard of care treatment for human epidermal growth factor receptor 2 (HER2) positive early breast cancer does not improve pathologic response outcomes
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.