Parathyroidectomy does not impact renal function in adults with primary hyperparathyroidism
1. In this target emulation trial, parathyroidectomy did not affect long-term renal function in adults with primary hyperparathyroidism (PHPT). 2....
Nephrology
Reports of high-impact nephrology studies by medical professionals
Incongruency between patients’ values and comfort-focused care on maintenance dialysis
1. Among patients undergoing maintenance dialysis, nearly half of patients valued comfort-focused care over life-prolonging care if they were to...
Risk factors for blood vessel rupture during vascular access intervention therapy for hemodialysis patients
1. In vascular access intervention therapy (VAIVT) for hemodialysis patients, patient factors for vessel rupture include lower BMI, fewer prior...
Inaxaplin reduces proteinuria in focal segmental glomerulosclerosis with two APOL1 variants
1. In preclinical studies, inaxaplin selectively inhibited apolipoprotein L1 (APOL1) in vitro and reduced proteinuria in a APOL1 G2-homologous transgenic...
Febuxostat may be effective in preventing contrast-induced acute kidney injury
1. This randomized control trial found that febuxostat has a reno-protective effect that can reduce the incidence of contrast-induced acute...
Hydrochlorothiazide does not impact risk of kidney-stone recurrence
1. In this randomized controlled trial, among patients with recurrent kidney stones, hydrochlorothiazide did not alter the risk of symptomatic...
Nivolumab plus ipilimumab does not improve survival in post-nephrectomy patients with renal cell carcinoma
1. Disease-free survival in the placebo group was 50.7 months and was never reached in the intervention group; however, there...
Specific histopathologic renal lesions may be associated with increased risk of cardiovascular disease
1. Risk of major adverse cardiac events increased amongst patients with a specific glomerular disease, including non-proliferative glomerulopathy, renal vascular...
Sodium bicarbonate does not prevent declining kidney function in kidney transplant recipients
1. The mean eGFR slope was comparable among patients allocated to sodium bicarbonate and placebo over 24 months. 2. Sodium...
Ultrasound renal denervation associated with reduced blood pressure in the RADIANCE II, RADIANCE-HTN SOLO, and RADIANCE-HTN TRIO trials – A pooled analysis
1. In this patient-level pooled analysis of 3 randomized clinical trials, among 506 patients with hypertension, a greater reduction in...
