Reduced pneumococcal vaccine schedules non-inferior to WHO recommendations
1. In this cluster-randomized controlled trial, it was found that a pneumococcal conjugate vaccine (PCV) schedule involving a single primary...
Pulmonology
Reports of high-impact pulmonology studies by medical professionals
RAMOSE Phase II trial finds promising results for osimertinib and ramucirumab in non-small cell lung cancer
1. Treatment of patients with tyrosine kinase inhibitor (TKI)-naïve epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) with...
Point of care C-reactive protein testing may be useful in guiding antibiotic prescribing
1. C-reactive protein (CRP)-point-of-care tests can be used to guide antibiotic prescribing in primary care for patients with acute exacerbations...
Amivantumab plus lazertinib improves survival in EGFR-mutated advanced NSCLC
1. In this randomized trial, amivantamab-lazertinib led to significantly longer progression-free survival than osimertinib therapy for mutated advanced non-small-cell lung...
Asthma may be associated with impaired memory function in children
1. Longitudinal results found that children with earlier asthma onset had slower episodic memory development compared to children without asthma....
Adjuvant durvalumab therapy improves survival in limited-stage small cell lung cancer
1. In this randomized controlled trial, adjuvant therapy with durvalumab led to improved overall and progression-free survival compared to placebo...
Perioperative pembrolizumab improves survival in resectable early-stage non-small cell lung cancer
1. 36-month overall survival and median event-free survival were significantly greater in the pembrolizumab group compared to control. 2. Grade...
Ziresovir reduces the severity of respiratory syncytial virus in hospitalized infants
1. Ziresovir, an antiviral drug targeted at respiratory syncytial virus (RSV), was superior to placebo in reducing signs and symptoms...
Active mechanical circulatory support does not reduce mortality in acute myocardial infarction-related cardiogenic shock
1. Early use of mechanical circulatory support did not reduce 6-month all-cause mortality. 2. MCS was associated with increased major...
Oxygen therapy for 15 versus 24 hours per day does not change hypoxemia-related mortality
1. In this randomized controlled trial, among patients with severe hypoxemia, long-term oxygen therapy used for 24 hours per day...
