![Adverse pregnancy outcomes associated with thrombophilias [Classics Series]](https://www.2minutemedicine.com/wp-content/uploads/2015/07/Classics-2-Minute-Medicine-e1436017941513-350x250.png)
The MADIT-CRT trial: Cardiac resynchronization therapy in heart failure [Classics Series]
1. In patients with heart failure, reduced left ventricular ejection fraction, and prolonged QRS>130 ms, treatment with cardiac resynchronization therapy...
General Medicine Classics
Physician-written reports of landmark medical studies
The EMGT: Reducing intraocular pressure slows progression of glaucoma [Classics Series]
1. Treatment using laser trabeculoplasty and topical betaxolol hydrochloride to reduce intraocular pressure (IOP) is associated with delayed progression of...
The RE-ALIGN trial: Dabigatran vs. warfarin for mechanical heart valves [Classics Series]
1. In patients with mechanical heart valves, anticoagulation with dabigatran was associated with significantly higher rates of stroke and major...
The CHARM-Added trial: Adding candesartan to ACE inhibitor reduces mortality in heart failure [Classics Series]
1. Angiotensin-converting-enzyme (ACE) inhibitors had been shown to significantly reduce mortality in patients with heart failure, and it was hypothesized...
The SOME trial: Screening for occult malignancy in unprovoked venous thromboembolism [Classics Series]
1. Patients with a first unprovoked venous thromboembolism were randomized to either limited-screening for occult malignancy or limited-screening plus computed...
Voriconazole superior to amphotericin B for invasive aspergillosis [Classics Series]
1. In immunocompromised patients with invasive aspergillosis, treatment with voriconazole was found to be superior to amphotericin B in achieving...
Ceftriaxone vs. norfloxacin for prophylaxis in patients with cirrhosis and gastrointestinal bleeding [Classics Series]
1. In cirrhotic patients who presented with gastrointestinal bleeding, patients treated with ceftriaxone were significantly less likely to develop proved...
The CONSENSUS: Enalapril reduces mortality in severe heart failure [Classics Series]
1. In patients with severe heart failure, treatment with enalapril significantly reduced the risk of mortality at 6-months and 1-year...
The SPAF trial: Warfarin and aspirin reduce the risk of stroke in atrial fibrillation [Classics Series]
1. Patients with atrial fibrillation are at higher risk of ischemic stroke and systemic embolism. 2. Compared to placebo, warfarin...
The BRIDGE trial: Periprocedural bridging in patients with atrial fibrillation [Classics Series]
1. Patients with atrial fibrillation are often treated with long-term oral anticoagulation, and may require interruption of their anticoagulation for...
