• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Gastroenterology

Pembrolizumab linked to longer cancer-free period in advanced colon cancer

byRicha SharmaandDeepti Shroff Karhade
January 24, 2021
in Gastroenterology, Oncology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In a phase 3 trial across 23 countries, Pembrolizumab displayed a longer cancer-free period when compared to the first line therapy for metastatic microsatellite instability or mismatch-repair deficiency (MSI-H-dMMR) colorectal cancer.

Evidence Rating Level: 1 (Excellent)

Study Rundown: A subset of colorectal cancer tumors is mismatch-repair deficiency (dMMR) which has been known to be the leading cause of colorectal cancer in 15% of those diagnosed. However, there is sufficient evidence that suggests that current first line chemotherapy does not produce the desired response. This study was conducted as a multicenter, open-label, randomized control trial that compared pembrolizumab with the recommended first line chemotherapy as suggested by the investigator for MSI-H-dMMR metastatic colorectal cancer. The follow up period for this study was 32.4 months where the patients were randomized into standard-of-care chemotherapy or pembrolizumab. This study also examined adverse effects, disease progression, mean survival, progression-free survival, overall survival, response rate, and efficacy among other things. Overall, pembrolizumab displayed a higher response rate when compared to traditional chemotherapy. Similar adverse events were noted in both groups.

This study was successful at randomizing a large sample size and collecting data over a long course.

Click to read the study in NEJM

Relevant Reading: Mutational Analysis of Patients With Colorectal Cancer in CALGB/SWOG 80405 Identifies New Roles of Microsatellite Instability and Tumor Mutational Burden for Patient Outcome

In-Depth [randomized controlled trial]: This open label, phase 3 trial was conducted across 23 countries where 307 patients were assigned randomly into one of two groups at 192 sites between February 2016 to February 2018. Patients were eligible if over 18 years of age, with radiologically confirmed and diagnosed MSI-H-dMMR stage IV colorectal cancer, with normal to adequate organ function. Patients were excluded from the study if they received previous adjuvant chemotherapy for this condition in the last six months. One group was given 200 mg of pembrolizumab intravenously every 3 weeks. The other group was given chemotherapy (mFOLFOX6, mFOLFOX6 plus bevacizumab, mFOLFOX6 plus cetuximab, FOLFIRI, FOLFIRI plus bevacizumab or FOLFIRI plus cetuximab) every 2 weeks based on the investigator’s choice of first line therapy for metastatic MSI-H-dMMR colorectal cancer. A maximum number of treatments was assigned to Group A, unless the patient wanted to withdraw from trial, or physician’s opinion was to withdraw the patient from the trial, or the patient developed serious side effects or illness during the course of treatment. Further assessments were conducted by using polymerase-chain-reaction-based analysis and imaging along with ongoing evaluation of side effects and/or adverse events. Overall, the power of the study was approximated at 98%, mean age of patients was 63, median time of treatment exposure was 11.1 months in pembrolizumab group and 5.7 months in the chemotherapy group. The study results indicate that the pembrolizumab group displayed longer progression-free survival when compared to the chemotherapy group with an overall response rate of 83% and 35%, respectively. The most common side effects of pembrolizumab were diarrhea, fatigue and nausea versus for the chemotherapy group, diarrhea, nausea and fatigue.

RELATED REPORTS

Adenoma detection rate is inversely associated with post-colonoscopy colorectal cancer risk

#VisualAbstract: Neoadjuvant–Adjuvant vs. Adjuvant-Only Pembrolizumab in Advanced Melanoma

#StudyGraphics: Concomitant chemoradiotherapy improves survival in elderly adults with locally advanced head and neck squamous cell carcinoma

Image: PD

©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: cancercolorectal cancerPembrolizumab
Previous Post

Focused ultrasound subthalamotomy revealed improvement in Parkinson’s patients

Next Post

REGN-COV2 antibody cocktail may reduces viral load in Covid-19 patients

RelatedReports

Benefits of high-intensity surveillance following colorectal adenoma removal likely outweigh costs
Chronic Disease

Adenoma detection rate is inversely associated with post-colonoscopy colorectal cancer risk

March 20, 2023
#VisualAbstract: Neoadjuvant–Adjuvant vs. Adjuvant-Only Pembrolizumab in Advanced Melanoma
StudyGraphics

#VisualAbstract: Neoadjuvant–Adjuvant vs. Adjuvant-Only Pembrolizumab in Advanced Melanoma

March 9, 2023
#StudyGraphics: Concomitant chemoradiotherapy improves survival in elderly adults with locally advanced head and neck squamous cell carcinoma
StudyGraphics

#StudyGraphics: Concomitant chemoradiotherapy improves survival in elderly adults with locally advanced head and neck squamous cell carcinoma

March 9, 2023
Adding sargramostim to ipilimumab may improve survival in advanced melanoma
Oncology

Neoadjuvant–Adjuvant vs. Adjuvant-Only Pembrolizumab in Advanced Melanoma

March 6, 2023
Next Post
Decreased expression of nasal ACE2 may be correlated with lower prevalence of COVID-19 in children

REGN-COV2 antibody cocktail may reduces viral load in Covid-19 patients

CD45 T cell and macrophage infiltration characteristic of COVID-19 related lung injury

2 Minute Medicine Rewind January 25, 2021

Adalimumab aids in control of noninfectious uveitis

Schoolchildren aged 6-8 years experiencing increased prevalence of myopia following house confinement from COVID-19

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Childhood maltreatment may cause mental health problems
  • #VisualAbstract: Hydrochlorothiazide does not impact risk of kidney-stone recurrence
  • Metformin use may decrease risk of osteoarthritis development
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options