• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Obstetrics

PTSD and major depressive episode linked with preterm birth

byMichael MilliganandJames Jiang
June 14, 2014
in Obstetrics, Psychiatry
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. Women likely experiencing posttraumatic stress disorder and major depressive episodes during pregnancy may be at a 4-fold increased risk of preterm birth. 

2. The association of posttraumatic stress disorder and major depressive episodes with preterm birth is independent of many potential confounders, including other mood and anxiety symptoms and use of antidepressants and benzodiazepines. 

Evidence Rating Level: 2 (Good)           

Study Rundown: Preterm birth, defined as a birth earlier than 37 weeks of gestation, is a leading cause of infant mortality worldwide, and has been associated with psychosocial stress. This study sought to unambiguously characterize the association between severe stress-related conditions like posttraumatic stress disorder (PTSD) and preterm birth. Women were recruited to the study before their 17th week of gestation and exposures of major depressive episodes (MDE) and PTSD were assessed using the validated CIDI and MPSS surveys respectively.

Analysis showed that there was a significant interaction between a diagnosis of PTSD and a diagnosis of MDE and together, these exposures led to a 4-fold increase in the risk of experiencing preterm birth. Preterm birth was also independently associated with SRI use, history of previous preterm birth, and increasing maternal age. The authors did find significance between PTSD and MDE and increased preterm birth risk, but it is important to note the confidence interval was quite wide. Though this study may be limited by the design and delivery of surveys to assess PTSD and MDE, it is the first study to find a significant and biologically plausible connection between maternal stress disorders and preterm birth.

Click to read the study in JAMA Psychiatry

Relevant Reading: Social adversity, low birth weight, and preterm delivery

RELATED REPORTS

Exercise improves symptoms in adults with depression

Wellness Check: Exercise

Youth depression and anxiety rates increased during the COVID-19 pandemic

In-Depth [prospective cohort]: This study followed 2654 women who were recruited before the 17th week of their pregnancy. CIDI and MPSS surveys were administered each trimester and found that 129 women (4.9%) in total screened positive for PTSD. Of 9525 volunteers, 1905 screened positive for prior depressive episodes, antidepressant treatment, PTSD, or MDE and were matched with a randomly selected cohort of 1612 women who did not have the exposures. 2654 women from this cohort had a singleton live birth and were included in this study.

Preterm birth was not significantly associated with women who had only PTSD or only MDE. However, women with PTSD were likely to also experience MDE and when analyzed together, these exposures were associated with a 4-fold increased risk of preterm birth (OR: 4.08, 95% CI: 1.27–13.15). Women with subsyndromal PTSD were also found to have a 3.82 times increased risk for preterm birth when calculated with MDE (95% CI: 1.29–1128). The MPSS is scored on a range from 0 to 110, and each point increase in the score was associated with a 1% to 2% increase in the odds of a preterm birth. Other factors significantly associated with risk of preterm birth were independent of the effect of PTSD and MDE and included a history of previous preterm birth (OR: 4.37; 95% CI: 3.02–6.33), serotonin reuptake inhibitor use (OR: 1.55; 95% CI: 1.02–2.36), and increasing maternal age (OR: 0.62; 95% CI: 0.45–0.85).

More from this author: Oxytocin therapy improves sociocommunicational deficits in patients with autism, Intravitreal melphalan provides tumor control of vitreous retinoblastoma seeds, High volume geriatric trauma facilities provide better geriatric trauma outcomes, Laparoscopic Sleeve Gastrectomy does not reliably improve GERD symptoms, Active video games may improve pediatric weight management programs, Arterial stiffening associated with β-Amyloid deposition, Age, bone mineral density may predict fracture after alendronate discontinuation

Image: PD

©2012-2014 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT.  

Tags: depressionpreterm birthsptsd
Previous Post

Trastuzumab associated with increased reversible cardiac changes

Next Post

Possible genetic marker for type 2 diabetes in Latinos identified

RelatedReports

Parents often unaware of adolescents’ suicidal thoughts
Lifestyle

Exercise improves symptoms in adults with depression

March 13, 2023
Adolescents’ muscle strength associated with lower cardiometabolic risk
Wellness

Wellness Check: Exercise

March 9, 2023
Association of Use of Oral Contraceptives With Depressive Symptoms Among Adolescents and Young Women
Pediatrics

Youth depression and anxiety rates increased during the COVID-19 pandemic

February 17, 2023
Quick Take: Effect of Developmentally Adapted Cognitive Processing Therapy for Youth With Symptoms of Posttraumatic Stress Disorder After Childhood Sexual and Physical Abuse
Wellness

Wellness Check: Mental Health

February 16, 2023
Next Post
Updated USPSTF guidelines favor treatment of mild gestational diabetes

Possible genetic marker for type 2 diabetes in Latinos identified

Clinic intervention reduces pregnancy risk behaviors in vulnerable youth

Contraceptive prior to first intercourse linked with improved reproductive outcomes

Palliative chemotherapy associated with more ICU treatment at end-of-life

Targeting Children’s Asthma Care measures reduced asthma readmission rates

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Active surveillance strategies to improve rates of inferior vena cava filter retrieval
  • Intranasal vaccine against Bordetella pertussis invokes seronegative IgA response
  • Hydrochlorothiazide does not impact risk of kidney-stone recurrence
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options