• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Radiofrequency renal denervation produces long-lasting reductions in blood pressure

byJessie WillisandTeddy Guo
April 20, 2022
in Cardiology, Chronic Disease, Nephrology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. The intervention group saw a 10 mmHg greater reduction in 24-h mean systolic blood pressure compared to the sham group at 36 months.

2. There was no difference in adverse events between the two groups and no difference seen in serum creatinine and eGFR after 36 months.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Hypertension is a major cause of premature death worldwide with numerous different targeted pharmaceuticals on the market. An interventional treatment method called renal denervation has been shown to lower blood pressure with antihypertensives in previous studies. The SPYRAL HTN-ON MED trial enrolled 80 patients with poorly controlled hypertension on antihypertensives. The participants were randomized 1:1 to undergo either radiofrequency ablation of their renal arteries and branch vessels or a sham control intervention. The study found that compared to the sham control group, patients who underwent renal denervation had a significant reduction in blood pressure after 24 months. This reduction was greater at the 36-month time point. There were no adverse events or variations in renal function blood tests related to the renal denervation treatment. Limitations of this study include the inability to perform full surveillance of compliance of prescribed antihypertensives, which were continued throughout the study. Nonetheless, this study presents promising results regarding the safety and efficacy of renal denervation with antihypertensives to combat hypertension.

Click to read the study in The Lancet

Relevant Reading: Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis

In-Depth [randomized control trial]: The SPYRAL HTN-ON MED trial was a randomized sham-controlled trial. Eligibility criteria included a systolic blood pressure between 150-180 mmHg, diastolic ≥ 90 mmHg and mean 24-h systolic blood pressure of 140-170 mmHg. Patients were on one to three antihypertensive medications prior to study enrollment. 80 patients were randomly assigned 1:1 to receive either renal denervation (n=38) or sham control (n=42). The procedure of renal denervation utilized radiofrequency ablations of the renal arteries and branch vessels. Patients remained on their prescribed blood pressure medication regimen during the study period.

RELATED REPORTS

Hydrochlorothiazide does not impact risk of kidney-stone recurrence

Nivolumab plus ipilimumab does not improve survival in post-nephrectomy patients with renal cell carcinoma

Sodium bicarbonate does not prevent declining kidney function in kidney transplant recipients

After 36 months, there were no significant differences in the antihypertensive burden between the two groups. However, at 36 months, the reduction in systolic blood pressure was -18.7 mm Hg for the intervention group and -8.6 mm Hg for the sham control group (adjusted treatment difference -10.0 mm Hg, 95% CI -16.6 to -3.3, p=0.0039). This demonstrated a further reduction from the values recorded at 24 months. There was no difference in eGFR, serum creatinine, sodium levels and potassium levels between the two groups at 24 and 36 months. There were three severe safety events during the 36 months: one death of unknown cause in the sham group and one stroke and hypertensive crisis in the treatment group. There were no cases of renal artery stenosis or need for re-intervention in the treatment group.

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: antihypertensivesblood pressureblood pressure controlhypertensionnephrologyrenal denervation
Previous Post

Prenatal exposure to maternal autoimmune diseases associated with increased risks of mental disorders in offspring

Next Post

Wellness Check: Addictions

RelatedReports

Renal stones in women linked with increased risk of coronary heart disease
Nephrology

Hydrochlorothiazide does not impact risk of kidney-stone recurrence

March 22, 2023
Tenofovir disoprovil fumarate HIV prophylaxis linked with minimal kidney impact
Chronic Disease

Nivolumab plus ipilimumab does not improve survival in post-nephrectomy patients with renal cell carcinoma

March 21, 2023
Tenofovir disoprovil fumarate HIV prophylaxis linked with minimal kidney impact
Chronic Disease

Sodium bicarbonate does not prevent declining kidney function in kidney transplant recipients

March 15, 2023
UTI associated with increased risk of preeclampsia
Cardiology

Ultrasound renal denervation associated with reduced blood pressure in the RADIANCE II, RADIANCE-HTN SOLO, and RADIANCE-HTN TRIO trials – A pooled analysis

March 6, 2023
Next Post
Quick Take: Effect of Pregabalin on Radiotherapy-Related Neuropathic Pain in Patients With Head and Neck Cancer: A Randomized Controlled Trial

Wellness Check: Addictions

Quick Take: Effect of Pregabalin on Radiotherapy-Related Neuropathic Pain in Patients With Head and Neck Cancer: A Randomized Controlled Trial

Adjuvant antipsychotic use in children treated for depression may be associated with movement disorders

No difference in PET-CT surveillance versus planned neck dissection in advanced head and neck cancer

Elevated neutrophil-lymphocyte ratio associated with poor prognosis for head and neck cancer

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Transcarotid artery revascularization not associated with a significant difference in 30-day risk of stroke, death and myocardial infarction compared to carotid endarterectomy
  • Drinking characteristics in adolescence predict alcohol behaviors in early adulthood
  • Sodium-glucose co-transporter-2 inhibitors may decrease risk of in-stent thrombosis
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options