Tag: hypertension

1. In a large, national sample, approximately 37.1% of patients with stroke history had uncontrolled blood pressure. 2. Most patients on medication were taking angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, diuretics, or calcium channel blockers. Evidence Rating Level: 2 (Good) Stroke is ranked as a leading cause of mortality and disability in...

Characteristics and Strength of Evidence of COVID-19 Studies Registered on ClinicalTrials.gov 1. While there has been a rise in clinical trials on COVID-19, a large proportion of these studies are expected to yield low levels of evidence. Evidence Rating Level: 3 (Average) The rapid and widespread transmission of coronavirus disease 2019 (COVID-19)...

1. Incidence of intracerebral hemorrhage in older patients has increased since 1948. 2. Hypertension and statin use are both associated with intracerebral hemorrhage. Evidence Rating Level: 3 (Average) Study Rundown: Of all stroke types, intracerebral hemorrhage (ICH) possesses the highest mortality rate and is the greatest cause of disability. While stroke incidence...

1. Amongst the five examined classes of antihypertensive medications (ACE Inhibitors, ARBs, beta blockers, calcium-channel blockers, and thiazide diuretics), none were associated with a substantial increase in likelihood of COVID-19. Evidence Rating: 2 (Good) Infection of host cells by SARS-CoV-2 is mediated via an interaction with membrane-bound angiotensin-converting enzyme (ACE) 2,...

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial 1. Adults with severe COVID-19 treated with remdesivir had numerically faster time to clinical improvement compared to controls, but the difference was not statistically significant Evidence Rating: 1 (Excellent) Months into declaration of COVID-19 as a pandemic, there still remains...

1. While chlorthalidone is the recommended thiazide diuretic treatment for hypertension, it has no added benefits compared to hydrochlorothiazide and has significantly worse safety profile. Evidence Rating Level: 1 (Excellent) The American College of Cardiology/American Heart Association hypertension guideline reported in 2017 that the recommended thiazide diuretic treatment for hypertension is currently...

1. Workplace wellness programs and health promotion may be an effective addition to standardized management of hypertension to improve health outcomes of employees. Evidence Rating: 1 (Excellent) Globally, it is estimated that roughly a quarter of the World’s population has hypertension. Despite appropriate blood pressure (BP) control being a priority given...

1. Large variations in blood pressure, including large rises and falls in blood pressure, over a period of years is associated with an increased long-term risk of dementia. Evidence Rating: 1 (Excellent) Dementia is highly prevalent affecting in the elderly, and represents a major burden to the healthcare system given...

Severe Lung Injury Associated With Use of e-Cigarette, or Vaping, Products - California, 2019 1. Study findings suggest that use of THC-containing products and vitamin E acetate to be associated with outbreak of use-associated lung injury in California Evidence Level: 3 (Average): Despite e-cigarette, or vaping usage increasing in popularity in North...

1. While chlorthalidone is the recommended thiazide diuretic treatment for hypertension, it has no added benefits compared to hydrochlorothiazide and has significantly worse safety profile. Evidence Rating Level: 1 (Excellent) The American College of Cardiology/American Heart Association hypertension guideline reported in 2017 that the recommended thiazide diuretic treatment for hypertension is...