Tag: hypertension

1. In this randomized, controlled trial, patients without cardiovascular disease randomized to receive a polypill containing atorvastatin, amlodipine, losartan, and hydrochlorothiazide experienced greater reductions in systolic blood pressure and low-density lipoprotein (LDL) cholesterol over 12 months compared to patients who received usual-care. 2. Polypill patients reported increased rates of myalgia,...
1. In this randomized, controlled trial, patients without cardiovascular disease randomized to receive a polypill containing atorvastatin, amlodipine, losartan, and hydrochlorothiazide experienced greater reductions in systolic blood pressure and low-density lipoprotein (LDL) cholesterol over 12 months compared to patients who received usual-care. 2. Polypill patients reported increased rates of myalgia,...
1. Potassium binder therapy with patiromer can promote longer duration of spironolactone use for resistant hypertension in the setting of chronic kidney disease. Evidence Rating Level: 1 (Excellent) Spironolactone is recommended in the treatment of resistant hypertension, however there is limited data regarding its use in the setting of chronic kidney...
1. In this prospective cohort study, higher 24-hour and nighttime blood pressure measurements were significantly associated with greater risks of death and a composite cardiovascular (CV) outcome. 2. 24-hour and nighttime blood pressure may be considered optimal measurements for estimating CV risk however, there was only a very modest improvement...
1. In this large, retrospective cohort study of veteran’s health administration (VHA) hospitals, males admitted to the hospital for non-cardiac reasons who had an intensification of their antihypertensive regimen before discharge had an increased risk of readmission and serious adverse events. 2. There was no difference in cardiac events or...
Hypertension commonly affects women in pregnancy, and is associated with adverse effects for both mother and baby. Currently, there is a lack of consensus on the relative efficacy and safety of oral medications used in treating severe hypertension in pregnancy, defined as systolic blood pressure of at least 160...
1. In this prospective cohort study, patients with midlife hypertension and either late-life hypertension or hypotension had higher risks of dementia than mid-life normotensive participants. 2. Midlife hypertension and late-life hypotension were also associated with greater risk of mild cognitive impairment. Evidence Rating Level: 2 (Good) Study Rundown: Though midlife hypertension has...
1. In this prospective cohort study, higher 24-hour and nighttime blood pressure measurements were significantly associated with greater risks of death and a composite cardiovascular (CV) outcome. 2. 24-hour and nighttime blood pressure may be considered optimal measurements for estimating CV risk however, there was only a very modest improvement...
The prevalence of hypertension is rapidly increasing in low-income and middle-income countries (LMICs). To effectively target interventions and monitor progress in hypertension care, it is essential to determine country-specific deficiencies in the hypertension care continuum. However, estimates of health system performance in hypertension care from nationally representative studies in...
Association of Immune Marker Changes With Progression of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma Multiple myeloma often develops from the precursor condition monoclonal gammopathy of undetermined significance (MGUS), which is detectable in peripheral blood. Similarly, the light-chain subtype of multiple myeloma is preceded by light-chain MGUS. Clinical guidelines...