Tag: hypertension

1. Black African patients with hypertension randomized to multiple two-drug combinations experienced greater blood pressure control when treated with amlodipine plus either hydrochlorothiazide or perindopril compared to those treated with perindopril plus hydrochlorothiazide. 2. Adverse event rates were similar in all three treatment groups. Evidence Rating Level: 1 (Excellent)   Study Rundown:...

Understanding the burden of health conditions in older adults in the U.S. is essential in addressing the healthcare demands of this patient population. This is of particular importance as the life expectancy in the U.S. continues to advance. In this retrospective cohort study, investigators analyzed data from 1998-2014 that...

In low and middle-income countries, the implementation of evidence-based therapies for cardiovascular disease, including the use of statins, antiplatelet therapy and anti-hypertensive medications, remains a challenge, despite high associated morbidity and mortality. In this cluster randomized controlled trial, 1619 patients with established atherosclerotic disease from 40 public and private...

Association of Racial Disparities With Access to Kidney Transplant After the Implementation of the New Kidney Allocation System There are many reasons why a patient may be made inactive on the kidney transplant waiting list, including psychosocial or financial issues or medical comorbidities. This has important implications for a patient’s...

1. Meta-analysis of sham-controlled randomized trials of catheter-based renal denervation demonstrated reduction in ambulatory and office systolic blood pressures. 2. Second-generation trials demonstrated greater reduction in ambulatory systolic blood pressure compared to first generation trials. Evidence Rating Level: 1 (Excellent) Study Rundown: Hypertension is one of the most common adult diseases and...

1. In this retrospective cohort study from Israel, hypertension at the age of 16-19 years old was linked with later-life end stage renal disease (ESRD). 2. The association between adolescent hypertension and ESRD remained after accounting for co-morbid conditions such as obesity, and after excluding those with severe hypertension. Evidence Rating...

1. In this randomized controlled trial, intensive blood pressure lowering in elderly patients reduced the risk of developing Mild Cognitive Impairment (MCI) compared to standard blood pressure lowering. 2. While there was no difference in the risk of dementia between groups, the trial was terminated early due to observed cardiovascular...

1. In this systematic review and meta-analysis, routine office systolic blood pressure readings were, on average, higher than automated office blood pressure readings. 2. Awake ambulatory blood pressure monitoring results were similar to automated office blood pressure monitoring. Evidence Rating Level: 1 (Excellent) Study Rundown: Hypertension is a well-established cardiovascular risk factor...

1. In this randomized controlled trial, intensive blood pressure lowering in elderly patients reduced the risk of developing Mild Cognitive Impairment (MCI) compared to standard blood pressure lowering. 2. While there was no difference in the risk of dementia between groups, the trial was terminated early due to observed cardiovascular...

1. In this randomized controlled trial, patients receiving triple combination antihypertension therapy (TCAT) were more likely to achieve their blood pressure target compared to those with usual care at 6 months. 2. There were no significant differences in the number of patients who withdrew from the study due to...