Tag: anemia

1. In patients with CKD, fixed low dose of erythropoietin provides similar efficacy outcomes, such as percentage of patients requiring transfusions, as titration-based dosing based on Hgb levels while decreasing cumulative dose of erythropoietin needed. Evidence Rating Level: 1 (Excellent) Chronic kidney disease (CKD) patients have parenchymal loss leading to decreased...
1. Intravenous iron prior to major abdominal surgery in anemic patients was not associated with decreased need for blood transfusions post-operation. 2. Preoperative intravenous iron did reduce the risk of readmission to hospital due to postoperative complications in anemic patients. Evidence Rating Level: 1 (Excellent) Study Rundown: Preoperative anemia is a common...
1. Anemia increased the risk of development of Crohn’s disease, inversely to hemoglobin concentration 2. Anemia was not associated with an increased risk of ulcerative colitis. Evidence Rating Level: 2 (Good) Though inflammatory bowel disease (IBD) can lead to anemia, whether anemia may be a surrogate marker for the early detection of...
1. In this secondary analysis of data from the CANTOS trial in 2017, canakinumab significantly reduced the incidence of anemia in patients with a history of myocardial infarction. 2. Among participants with baseline anemia, those who received canakinumab had significantly higher hemoglobin levels versus placebo. Evidence Rating Level: 3 (Average) Study Rundown:...
1. In African children with uncomplicated severe anemia, immediate blood transfusion did not notably alter patient mortality at 1- or 6-months post treatment compared to patients treated under current practice. 2. Rates of hospital readmission, serious adverse events, and hemoglobin recovery were similar between the two groups. Evidence Rating Level: 1...
Chronic kidney disease (CKD)-related anemia is associated with significant morbidity, and remains undertreated worldwide. Adequate treatment of CKD-related anemia is associated with reduced transfusion rates and improved clinical outcomes. Roxadustat is a hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor that stabilizes HIF-alpha subunits, resulting in increased transcriptional activity and functional...
1. In African children with uncomplicated severe anemia, immediate blood transfusion did not notably alter patient mortality at 1- or 6-months post treatment compared to patients treated under current practice. 2. Rates of hospital readmission, serious adverse events, and hemoglobin recovery were similar between the two groups. Evidence Rating Level: 1...
Roxadustat for anemia in patients with kidney disease not receiving dialysis Chronic kidney disease (CKD)-related anemia is associated with significant morbidity, and remains undertreated worldwide. Adequate treatment of CKD-related anemia is associated with reduced transfusion rates and improved clinical outcomes. Roxadustat is a hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor that...
1. The authors observed in this retrospective cohort study that transfusion rates decreased among patients from 2010 and 2014. 2. Paralleling decreasing transfusion rates, the authors observed a reduction in 6-month mortality rates among patients with moderate anemia from 2010 and 2014. Evidence Rating Level: 2 (Good) Study Rundown: Anemia is a...
1. In this non-randomized, double-blind, placebo-controlled study, men 65 years or older who had unexplained anemia with low serum testosterone had an increase in their measured serum hemoglobin with testosterone replacement. 2. Hemoglobin levels increased with testosterone therapy in patients with explained and unexplained anemia, as well as in non-anemic...