Tag: anemia

1. In this secondary analysis of data from the CANTOS trial in 2017, canakinumab significantly reduced the incidence of anemia in patients with a history of myocardial infarction. 2. Among participants with baseline anemia, those who received canakinumab had significantly higher hemoglobin levels versus placebo. Evidence Rating Level: 3 (Average) Study Rundown:...
1. In African children with uncomplicated severe anemia, immediate blood transfusion did not notably alter patient mortality at 1- or 6-months post treatment compared to patients treated under current practice. 2. Rates of hospital readmission, serious adverse events, and hemoglobin recovery were similar between the two groups. Evidence Rating Level: 1...
Chronic kidney disease (CKD)-related anemia is associated with significant morbidity, and remains undertreated worldwide. Adequate treatment of CKD-related anemia is associated with reduced transfusion rates and improved clinical outcomes. Roxadustat is a hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor that stabilizes HIF-alpha subunits, resulting in increased transcriptional activity and functional...
1. In African children with uncomplicated severe anemia, immediate blood transfusion did not notably alter patient mortality at 1- or 6-months post treatment compared to patients treated under current practice. 2. Rates of hospital readmission, serious adverse events, and hemoglobin recovery were similar between the two groups. Evidence Rating Level: 1...
Roxadustat for anemia in patients with kidney disease not receiving dialysis Chronic kidney disease (CKD)-related anemia is associated with significant morbidity, and remains undertreated worldwide. Adequate treatment of CKD-related anemia is associated with reduced transfusion rates and improved clinical outcomes. Roxadustat is a hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor that...
1. The authors observed in this retrospective cohort study that transfusion rates decreased among patients from 2010 and 2014. 2. Paralleling decreasing transfusion rates, the authors observed a reduction in 6-month mortality rates among patients with moderate anemia from 2010 and 2014. Evidence Rating Level: 2 (Good) Study Rundown: Anemia is a...
1. In this non-randomized, double-blind, placebo-controlled study, men 65 years or older who had unexplained anemia with low serum testosterone had an increase in their measured serum hemoglobin with testosterone replacement. 2. Hemoglobin levels increased with testosterone therapy in patients with explained and unexplained anemia, as well as in non-anemic...
Targeting Mutant BRAF in Relapsed or Refractory Hairy-Cell Leukemia BRAF V600E has been identified as the genetic lesion responsible for the development of hairy-cell leukemia.  In this study, researchers conducted two phase-2, single-group, multicenter trials looking at the effectiveness and safety of oral vemurafenib (a BRAF inhibitor) in patients with...
1. Maternal hemoglobin levels were measured at 2 antenatal visits and delivery, while their infants were followed 1 year later and assessed for gross motor (GM) functions. Prevalence of maternal anemia fell from 67% in the first antenatal visit to 38.4% at the time of delivery. 2. GM scores peaked...
Image: PD  1. Elderly anemic patients were found to have both an increased rate of mortality and cardiac events after elective open and endovascular procedures.  2. For every percentage point decrease in hematocrit from baseline, there was a 4.2% increase in the adjusted risk of 30-day postoperative mortality.  Evidence Rating Level: 2...