Tag: anemia

1. Older age, male sex, and pre-existing comorbidities were independent risk factors for developing complications following COVID-19 infection. 2. The most common complications included renal, complex respiratory, systemic, and cardiovascular. Evidence Rating Level: 2 (Good)  Study Rundown: Patients hospitalized with COVID-19 are likely to develop in-hospital complications which may worsen their prognosis....
1. Malaria case incidence was decreased in the intervention group (1.43 per child-year) compared to the control group (2.29 per child-year). 2. Screening plus Eave Tubes has a 74.0% chance of representing a cost-effective intervention for malaria protection. Evidence Rating Level: 1 (Excellent) Study Rundown: In recent years, wide scale implementation of...
1. Dihydroartemisinin-piperaquine was shown to prevent deaths of children with severe anemia in areas with intense malaria transmission compared to placebo. 2. Monthly chemoprevention with dihydroartemisinin-piperaquine was shown to reduce readmissions for any reason in children with severe anemia compared to placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: Severe anemia substantially contributes to...
1. Dihydroartemisinin-piperaquine was shown to prevent deaths of children with severe anemia in areas with intense malaria transmission compared to placebo. 2. Monthly chemoprevention with dihydroartemisinin-piperaquine was shown to reduce readmissions for any reason in children with severe anemia compared to placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: Severe anemia substantially...
1. In patients with CKD, fixed low dose of erythropoietin provides similar efficacy outcomes, such as percentage of patients requiring transfusions, as titration-based dosing based on Hgb levels while decreasing cumulative dose of erythropoietin needed. Evidence Rating Level: 1 (Excellent) Chronic kidney disease (CKD) patients have parenchymal loss leading to decreased...
1. Intravenous iron prior to major abdominal surgery in anemic patients was not associated with decreased need for blood transfusions post-operation. 2. Preoperative intravenous iron did reduce the risk of readmission to hospital due to postoperative complications in anemic patients. Evidence Rating Level: 1 (Excellent) Study Rundown: Preoperative anemia is a common...
1. Anemia increased the risk of development of Crohn’s disease, inversely to hemoglobin concentration 2. Anemia was not associated with an increased risk of ulcerative colitis. Evidence Rating Level: 2 (Good) Though inflammatory bowel disease (IBD) can lead to anemia, whether anemia may be a surrogate marker for the early detection of...
1. In this secondary analysis of data from the CANTOS trial in 2017, canakinumab significantly reduced the incidence of anemia in patients with a history of myocardial infarction. 2. Among participants with baseline anemia, those who received canakinumab had significantly higher hemoglobin levels versus placebo. Evidence Rating Level: 3 (Average) Study Rundown:...
1. In African children with uncomplicated severe anemia, immediate blood transfusion did not notably alter patient mortality at 1- or 6-months post treatment compared to patients treated under current practice. 2. Rates of hospital readmission, serious adverse events, and hemoglobin recovery were similar between the two groups. Evidence Rating Level: 1...
Chronic kidney disease (CKD)-related anemia is associated with significant morbidity, and remains undertreated worldwide. Adequate treatment of CKD-related anemia is associated with reduced transfusion rates and improved clinical outcomes. Roxadustat is a hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor that stabilizes HIF-alpha subunits, resulting in increased transcriptional activity and functional...