Tag: autoimmune disease

1. In relatives of patients with type 1 diabetes (T1DM) at risk for disease development, randomization to teplizumab delayed time to T1DM diagnosis compared to placebo treated patients. 2. Adverse events associated with teplizumab treatment included rash and transient lymphopenia. Evidence Rating Level: 1 (Excellent)   Study Rundown: T1DM results from autoimmune destruction...
1. In relatives of patients with type 1 diabetes (T1DM) at risk for disease development, randomization to teplizumab delayed time to T1DM diagnosis compared to placebo treated patients. 2. Adverse events associated with teplizumab treatment included rash and transient lymphopenia. Evidence Rating Level: 1 (Excellent)   Study Rundown: T1DM results from autoimmune...
Anti-tumor necrosis factor (TNF) therapies are commonly used in the treatment of patients with moderate to severe Crohn’s disease. However, due to the high costs of anti-TNF medications, biosimilar medications are being developed. These drugs have high likeness to already licensed biological therapies and are subject to strict approval...
1. In a prospective study of children at-risk for development of type-1 diabetes, antibiotic use was not associated with the development of islet or celiac disease autoimmunity. 2. The investigators accounted for geography, which can be a major confounding variable. Evidence Rating Level: 2 (Good)        Study Rundown: The increased prevalence of autoimmune...
Image: PD 1. High salt concentrations were found to activate a pathway involved in TH17 cell development in mice. 2. TH17 cells generated within concentrated salt conditions produce pro-inflammatory cytokines associated with autoimmune diseases. There have been increases in autoimmune disease incidence over the last fifty years with substantial research looking at...