Tag: dabigatran

1. In this observational study, patients who received one of three direct oral anticoagulants (DOACs) were significantly less likely to have an osteoporotic hip or vertebral fracture compared to those who received warfarin. 2. No difference in fracture risk was detected between individual DOACs. Evidence Rating Level: 2 (Good) Study Rundown: Osteoporotic...

Central venous thrombosis (CVT) is a form of stroke characterized by thrombosis of cerebral veins or dural sinuses. While less than 5% of the 1.3 to 1.6 per 100,000 who experience CVT die by this cause, those who survive are at an increased risk of venous thrombotic events, and...

Prehospital Stroke Management Optimized by Use of Clinical Scoring vs Mobile Stroke Unit for Triage of Patients with Stroke: A Randomized Clinical Trial The effective management of intracranial hemorrhage (ICH) or large-vessel occlusion (LVO) requires effective triaging to hospitals with appropriate treatment capabilities, ranging from comprehensive stroke centers (CSC) to...

1. The Perioperative Anticoagulation Use for Surgery Evaluation (PAUSE) cohort study evaluated the safety of standardized perioperative interruption of direct oral anticoagulants (DOACs) for patients with atrial fibrillation undergoing operative interventions. The rates of both major bleeding and arterial thrombosis were low during the study period. 2. Most patients had...

1. The analysis of data from more than 50,000 patients showed that both dabigatran and warfarin were associated with similar amounts of bleeding and rates of ischemic stroke. 2. Dabigatran is a safe alternative to warfarin for reducing the risk of stroke in patients with atrial fibrillation. Evidence Rating Level: 2...

Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation Patients with atrial fibrillation undergoing percutaneous coronary intervention (PCI) typically receive warfarin and two antiplatelet drugs as part of the current standard of care. However, studies have shown that this approach is associated with an increased risk of major bleeding....

1. The incidence of major bleeding events up to 8 weeks after catheter-directed atrial fibrillation ablation was significantly lower in those receiving continuous therapy with dabigatran compared to those receiving INR-directed warfarin. 2. Both groups experienced similar incidence of minor bleeding events and thromboembolic events. Evidence Rating Level: 1 (Excellent) Study Rundown:...

1. Based on a retrospective cohort study of US Medicare patients, rivaroxaban was associated with a significantly increased risk of intracranial and extracranial hemorrhage compared with dabigatran when used in elderly patients with nonvalvular atrial fibrillation for stroke prevention. 2. There was a trend towards a decrease in thromboembolic stroke...

1. In patients with mechanical heart valves, anticoagulation with dabigatran was associated with significantly higher rates of stroke and major bleeding when compared to warfarin. 2. Based on these findings, patients with mechanical heart valves should be anticoagulated with warfarin, as opposed to dabigatran. Original Date of Publication: September 2013 Study...