Tag: hormone replacement therapy

Hormone replacement therapy (HRT), often prescribed to women during menopause, has been shown to increase the risk for venous thromboembolism (VTE). However, the effects of different types of HRT preparations on the risk of VTE have not been thoroughly investigated. This case-control study enrolled women between the ages of...
An Evaluation of the Effects of Lowering Blood Alcohol Concentration Limits for Drivers on the Rates of Road Traffic Accidents and Alcohol Consumption: A Natural Experiment Individuals that drive while under the influence of alcohol are at an increased risk of being involved in traffic accidents, contributing to the morbidity...
1. In this analysis of two randomized controlled trials, hormone replacement therapy (HRT) was not associated with a change in all-cause mortality among post-menopausal women. 2. No change in cancer or cardiovascular mortality was associated with HRT. Evidence Rating Level: 1 (Excellent) Study Rundown: The Women’s Health Initiative Hormone Replacement Therapy (HRT)...
1. Cross-sex hormone therapy (CSHT) may be associated with worsening cardiovascular risk factors in transgender men. 2. CSHT may not result in increases in cardiovascular morbidity or mortality. Evidence Rating Level: 2 (Good) Study Rundown: Understanding the unique health care needs of the transgender population is highly important; approximately 1.4 million persons...
1. Women with a history of perimenopausal depression experienced an increase in severity of depression after estrogen withdrawal. 2. These women reported avoidance of socialization, sleep disturbances, and decreased motivation following discontinuation of hormone therapy. Evidence Rating Level: 1 (Excellent)       Study Rundown: Menopause denotes the permanent cessation of menstruation and is diagnosed...
1. In this meta-analysis of postmenopausal women with ovarian cancer, the risk of ovarian cancer was strongly associated with recent (<5 years) or current use of hormone replacement therapy but decreased with increasing time after cessation of therapy. 2. Applying the results to ovarian cancer incidence and death rates in...
Classics Series, Landmark Trials in Medicine
1. Combination estrogen and progestin hormone replacement therapy (HRT) is associated with a 29% increased risk of cardiovascular disease, 110% increased risk of venous thromboembolism and 26% increased risk of invasive breast cancer. 2. Over 1 year, 10 000 women taking combination HRT might experience 7 more cardiovascular events, 8...