Limiting antihypertensive use does not reduce mortality in nursing home residents with frailty
1. In this randomized clinical trial, among older nursing home residents with frailty who were being treated for hypertension with ...
Tag: internal medicine
Digitoxin improves outcomes in heart failure with reduced ejection fraction
1. Among patients with symptomatic chronic heart failure already on guideline-directed medical therapy (GDMT), digitoxin lowered all-cause mortality and hospital ...
Nerandomilast slows decline in FVC in idiopathic pulmonary fibrosis
1. In this randomized trial, among patients with idiopathic pulmonary fibrosis (IPF), nerandomilast slowed the decline in the forced vital ...
Nerandomilast slows FVC decline in progressive pulmonary fibrosis
1. In this randomized controlled trial, treatment with nerandomilast led to slower declines in forced vital capacity (FVC) in patients ...
AAV gene therapy shows durable benefit in hemophilia B
1. In this prospective cohort study, a single intravenous dose of scAAV2/8-LP1-hFIXco gene therapy in men with severe hemophilia B ...
Frailty scores alone may be poor predictors of intensive care admission or hospital stay duration
1. Frailty scores alone (mFI-5, CCI) are poor predictors of intensive care unit (ICU) admission or prolonged hospital stay in ...
Sotatercept reduces adverse event risk in high-risk pulmonary arterial hypertension
1. In this randomized controlled trial of patients with pulmonary arterial hypertension (PAH) and high risk of mortality, sotatercept reduced ...
Hereditary erythrocytosis is associated with a fetal-like EPO isoform
1. This case series identified three non-coding erythropoietin (EPO) variants that significantly increased gene expression under hypoxic conditions. 2. The ...
Risk of bloodstream infections with indwelling peripheral catheters increase after 3 days
1. The risk of bloodstream infections (BSIs) in individuals with indwelling peripheral intravenous catheters (PIVCs) is significantly increased after 3 ...
Genomic sequencing identifies variants linked to congenital diarrhea and enteropathies
1. In this cross-sectional study, nearly half of the infants with congenital diarrhea and enteropathies (CODEs) had identifiable causal variants, ...
