Tag: mechanical ventilation

1. Milrinone was shown not to be significantly different than dobutamine for the treatment of cardiogenic shock. 2. In-hospital deaths of patients treated with either milrinone or dobutamine were not significantly different. Evidence Rating Level: 1 (Excellent) Study Rundown: Cardiogenic shock is a state of low cardiac output causing end-organ hypoperfusion. Treatments...
1. Among patients hospitalized with severe COVID-19 and hyperinflammation, treatment using the anti-interleukin-1β antibody canakinumab, compared with placebo, did not significantly increase the likelihood of survival without invasive mechanical ventilation at day 29. 2. These findings for canakinumab vs placebo were also consistent for the secondary outcome of COVID-19-related mortality...
1. This phase III drug trial showed that dexamethasone does not significantly reduce risk of adverse events and death following major non-cardiac surgery. 2. Secondary safety outcomes were comparable between the dexamethasone and placebo groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Major surgery has potential major complications, such as shock, infection,...
1. Patients with prior episodes of critical illness requiring ICU admission were found to have an elevated risk of suicide and self-harm. 2. Suicide and self-harm were further correlated to the prevalence pre-existing psychiatric conditions as well as the receipt of life support. Evidence Rating Level: 2 (Good) Study Rundown: Due to...
1. Treatment with dexmedetomidine was shown not to differ from propofol treatment in adult patients with sepsis who were under mechanical ventilation. 2. No significant difference was found in functional, quality-of-life, or cognitive assessment scores between the two treatment methods. Evidence Rating Level: 1 (Excellent) Study Rundown: Sedative medications are often administered...
 1. In this single center quality improvement study, the use of any volume-targeted ventilation in premature infants increased by 16%, and exclusively volume-targeted ventilation increased by 280%. 2. Increased volume-targeted ventilation did not alter infant outcomes, including mortality, bronchopulmonary dysplasia, severe intraventricular hemorrhage, or duration of mechanical ventilation. Evidence Rating Level:...
1. In a single center quality improvement project, implementation of a clinical practice algorithm in mechanically ventilated patients in the pediatric ICU lead to a significant reduction in the number of endotracheal aspirate cultures (EACs) obtained. 2. Length of stay, mortality, and readmissions were unchanged despite the decrease in EACs. Evidence...
1. A web-based decision aid was developed to help improve communication between clinicians and patient-surrogates for patients with prolonged mechanical ventilation. 2. Physicians and families had very different expectations about patients’ prognoses, and this did not improve with the decision aid. Forty three percent of surrogates reported that the program...