Tag: Ophthalmology

1. For non-experts, sensitivity in diagnosing CMV retinitis ranged from 64.0% to 95.5% and specificity ranged from 65.6% to 92.5%. 2. When compared to the expert consensus as a standard, mean sensitivity and specificity for non-experts were 93.2% and 88.4% respectively. Evidence Rating Level: 2 (Good) Study Rundown: Cytomegalovirus (CMV) retinitis is a serious complication...
1. Both the 0.35mg and 0.7mg dexamethasone dosing led to a significant increase in visual acuity compared to sham. 2. Central retinal thickness, a measure of the extent macular edema, was decreased significantly in the 0.35mg and 0.7mg dexamethasone treatment groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Diabetic macular edema (DME),...
Image: PD 1. A significant association was observed with patients who were exposed to the outdoors for over 11 hours during the high school to 24 year period. 2. Although not statistically significant, females living closer to the equator who spent significant amount of time outdoors were found to have...
Image: PD 1. 8 predictors (age, sex, education level, race, smoking status, presence of pigment abnormality, soft drusen, and maximum drusen size) were utilized to create a macular risk scoring system (MRSS). 2. Area under the receiver operating characteristic (ROC) curve was excellent (internally validated c-index = 0.88; externally validated c-index...
Image: PD 1. At 24 months, frequency doubling perimetry (FDP) foveal sensitivity was significantly decreased in the placebo group (-1.9 dB) and increased in the group treated with Doxycycline (+1.8 dB, p=0.02). This difference was consistently observed beginning at 6 months. 2. There were no other significant differences between the placebo...
Image: PD 1. Outflow facility in cadaveric eyes increased from a baseline of 0.28 ± 0.10 µL/min/mmHg to 0.44 ± 0.13 µL/min/mmHg after implantation of the Hydrus microstent (p=0.001). 2. Compared to cadaveric eyes implanted with iStents, eyes implanted with the Hydrus scaffold had a significantly greater increase in outflow facility...
Image: PD 1. Three mitochondrial genes were found to have significantly different variants among normal-tension glaucoma (NTG) patients compared to control patients: COX3, ND2, and CYTB (56.5 vs. 44.4%, p=0.02; 28.4 vs. 15.3%, p=0.002; 3.1 vs. 0.0%, p=0.03 respectively). 2. Normal-tension glaucoma patients with thymine (T) at position 4883 within...
Image: PD 1. Students previously trained and who participated in service experience had a median exam score of 81% compared to 33% among untrained students and 44% among internal medicine residents (p<0.001). 2. These differences appear to disappear by 1 month and 1 year (p=0.24 and 0.11 respectively). Evidence Rating Level:...
Image: PD  1. Telemedicine screening for diabetic retinopathy is cost-effective in populations over 3,500 and under the age of 80. 2. The ratio of average cost per quality-adjusted life years (QALY) ranges from $20,000 to $46,500 depending on the population size, significantly lower than the economic benchmark of $50,000. Evidence Rating Level:...
Image: PD 1.  Cytokines previously not found to be associated with proliferative diabetic retinopathy (GM-CSF, IL-12p40, sCD40L, MCP-3, and IFNa2) were discovered to be significantly elevated in the vitreous humor of these patients independent of VEGF (p<0.05).  2. Age, hypertension, and smoking history were correlated with proliferative diabetic retinopathy, but not with...