Tag: tumor

1. Rapamycin (rapa) inhibited tumor initiation in Adenomatous polyposis coli gene (Apc)-deficient mouse intestinal epithelial cells, and enhanced survival in a mouse intestinal tumorigenesis model. 2. Translational elongation through the mTORC1 signaling pathway in Apc-deficient cells was identified as the mechanism targeted by such rapa treatment. Evidence Rating Level: 1...
1. Tumor response ratio reflects the portion of the tumor remaining after the patient undergoes neoadjuvant chemotherapy prior to any surgical resection of the tumor. 2. In this study, the tumor response ratio was found to be predictive of overall survival in breast cancer patients who underwent neoadjuvant chemotherapy.  Evidence Rating Level: 2...
Image: PD  1. In patients with hepatocellular carcinoma who underwent liver transplantation, response to transarterial chemoembolization and radiologic size of tumor were both shown to independently predict rates of recurrence.  2. Patients with no response to chemoembolization and a radiologic tumor size greater than 3 cm had a recurrence rate of...
Image: PD 1. Circulating tumor DNA was found to show significantly greater sensitivity in identifying metastatic breast cancer than other circulating biomarkers.  2. Using circulating tumor DNA to monitor metastatic breast cancer allows for more specific prognosis and evaluation during treatment. There are various treatments available for patients with breast cancer, however...