Tag: type 2 diabetes

1. Tirzepatide was superior to placebo with regard to changes in HbA1c, serum glucose, body weight loss, and proportion of patients achieving HbA1c targets of less than 7.0%. 2. Compared to placebo, the proportion of adverse events with tirzepatide were mildly elevated. Evidence Rating Level: 1 (Excellent) Study Rundown: In many patients...

1. Sotagliflozin treatment was shown to increase the days-alive-and-out-of-hospital compared to placebo in patients with type 2 diabetes and heart failure. 2. Sotagliflozin treatment was shown to significantly decrease the rate of days dead compared to the placebo treatment. Evidence Rating Level: 1 (Excellent) Study Rundown: Sodium-glucose cotransporter 2 (SGLT2) inhibitors have...

1. Widespread diabetes screening helps to identify asymptomatic patients with preserved renal function and low diabetes-associated cardiovascular risk. 2. New cardiovascular risk stratification strategies are needed given heterogeneous characteristics of patients with type 2 diabetes.  Evidence Rating Level: 2 (Good)  Study Rundown: In the last decade, New Zealand Ministry of Health has...

2 Minute Medicine is pleased to announce that we are launching Wellness Check, a new series dedicated to exploring new research evidence focused on wellness. Each week, we will report on articles examining different aspects of wellness, including (but not limited to) nutrition, sleep, reproductive health, substance use and...

1. Change in mean bodyweight was -9.6% with semaglutide 2.4 mg vs. -3.4% with placebo. 2. Approximately two-thirds of patients on semaglutide 2.4 mg achieved a target HbA1c of 6.5% or less.  Evidence Rating Level: 1 (Excellent) Study Rundown: There is strong overlap between weight gain and type 2 diabetes, with the...

1. Compared to patients of European descent, poorer health outcomes were seen among Māori and Pacific New Zealanders with type 2 diabetes. 2. Māori patients had the highest incidence rate of all-cause mortality, cardiovascular mortality, and cancer mortality. Evidence Rating Level: 2 (Good) Study Rundown: Disparities associated with ethnicity and socioeconomic status...

1. 10-year remission rates were significantly higher for Roux-en-Y gastric bypass (RYGB) and biliopancreatic diversion (BPD) than medical therapy. 2. Patients in the BPD and RYGB groups had fewer diabetes-related complications.  Evidence Rating Level: 1 (Excellent) Study Rundown: Compared to conventional therapy, metabolic surgery results in significant short-term improvements among patients with...

1. Sotagliflozin was shown to lower the risk of total number of deaths from cardiovascular causes and hospitalizations and urgent visits for heart failure in patients with diabetes and recent worsening heart failure compared to placebo. 2. Sotagliflozin was shown to be similar in the percentage of patients with adverse...

The association of depression with subsequent dementia diagnosis: A Swedish nationwide cohort study from 1964 to 2016 1. There is a significantly increased risk of dementia in patients with previously diagnosed depression, with the highest risk observed in patients diagnosed with severe depression Evidence Level: 2 (Good) The prevalence of dementia is on...