• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Bepirovirsen may reduce disease burden in patients with chronic hepatitis B

byDavid XiangandKiera Liblik
December 22, 2022
in Chronic Disease, Gastroenterology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. Bepirovirsen resulted in a sustained hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA loss in approximately 10% of participants with chronic HBV infection.

2. The bepirovirsen group had significantly increased adverse events compared to the placebo group. 

Evidence Rating Level: 1 (Excellent)

Study Rundown: Chronic HBV infection causes approximately 820,000 deaths yearly, with an estimated 1.5 million new infections annually. While therapy aims to achieve a functional cure, with HBsAg loss or sustained undetectable HBV DNA after cessation of therapy, this is uncommon in patients receiving prolonged treatment. In patients receiving prolonged nucleoside or nucleotide analog (NA) therapy (the first-line treatment for HBV), fewer than 5% of patients have HBsAg loss after 12 months of treatment. Bepirovirsen is a 2’-O-methoxy-ethyl modified antisense oligonucleotide, which targets all HBV RNAs, including HBV messenger RNA and pregenomic RNA. However, there is a gap in knowledge as to understanding the efficacy and safety of 12- and 24-week bepirovirsen treatment in participants with chronic HBV infection either receiving stable NA therapy or not receiving NA therapy. Overall, this study found that treatment with bepirovirsen resulted in HBsAg and HBV DNA loss for 24 weeks after the end of treatment. This study was limited by having short follow-up and a small participant pool. Nevertheless, these study’s findings are significant, as they demonstrate that bepirovirsen may be efficacious in treating chronic HBV in inducing a sustained loss of HBsAg and HBV DNA.

Click to read the study in NEJM

Relevant Reading: A Modern Therapy for an Ancient Disease

RELATED REPORTS

Sodium-glucose cotransporter 2 inhibitors may decrease risk of serious liver events in patients with cirrhosis

Early acetaminophen use reduces mortality risk in patients with sepsis-associated encephalopathy

2 Minute Medicine Rewind June 30, 2025

In-Depth [randomized controlled trial]: This phase two randomized, parallel cohort trial was conducted at 123 sites in 22 countries. Participants 18 years of age or older with documented chronic HBV infection for at least six months and an HBsAg level of more than 100 IU per milliliter were eligible for the study. The primary outcome measured was an HBsAg level below the lower limit of detection and an HBV DNA level below the lower limit of quantification maintained for 24 weeks after the planned end of bepirovirsen treatment. There were four treatment groups: bepirovirsen 300mg for 24 weeks (group 1), bepirovirsen 300mg for 12 weeks then 150mg for 12 weeks (group 2), bepirovirsen 300mg for 12 weeks then placebo for 12 weeks (group 3), and placebo for 12 weeks then bepirovirsen 300mg for 12 weeks (group 4). Based on the primary analysis, among those receiving NA therapy, a primary-outcome event occurred in six participants in group 1 (9%; 95% credible interval, 0 to 31), six in group 2 (9%; 95% credible interval, 0 to 43), two in group 3 (3%; 95% credible interval, 0 to 16), and zero in group 4 (0%; post hoc credible interval, 0 to 8). Among participants not receiving NA therapy, a primary-outcome event occurred in seven (10%; 95% credible interval, 0 to 38), four (6%; 95% credible interval, 0 to 25), one (1%; post hoc credible interval, 0 to 6), and zero participants (0%; post hoc credible interval, 0 to 8), respectively. Adverse events were more common with bepirovirsen (groups 1, 2, and 3) than with placebo (group 4). Overall, this study demonstrates that bepirovirsen at a dose of 300mg per week for 24 weeks resulted in sustained HBsAg and HBV DNA loss in 9-10% of participants with chronic HBV infection.

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: bepirovirsenchronic diseaseChronic hepatitis BGastroenterologygeneral surgeryHBVhepatitishepatitis bhepatitis b virushepatology
Previous Post

The majority of FDA-approved drug trials recruit from low- and middle-income countries

Next Post

Artificial rupture of membranes alone is effective for induction in women with previous C-section

RelatedReports

Low free sugar diet reduces hepatic steatosis in nonalcoholic fatty liver disease in adolescent males
Chronic Disease

Sodium-glucose cotransporter 2 inhibitors may decrease risk of serious liver events in patients with cirrhosis

July 2, 2025
Emergency

Early acetaminophen use reduces mortality risk in patients with sepsis-associated encephalopathy

July 1, 2025
Quick Take: Functional Outcome of Intravenous Thrombolysis in Patients With Lacunar Infarcts in the WAKE-UP Trial
Weekly Rewinds

2 Minute Medicine Rewind June 30, 2025

June 30, 2025
Chronic Disease

Weighted vests and resistance training confer similar outcomes for bone density in the elderly

June 27, 2025
Next Post
Maternal vaccination during pregnancy not associated with infant hospitalization, mortality

Artificial rupture of membranes alone is effective for induction in women with previous C-section

Bystander and first-responder initiated CPR associated with improved outcomes

Smartphone dispatch of volunteer responders may not increase bystander use of automated external defibrillator in out-of-hospital cardiac arrest – the SAMBA trial

Eczema more prevalent among older adults than previously thought

2 Minute Medicine Rewind December 12, 2022

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Sodium-glucose cotransporter 2 inhibitors may decrease risk of serious liver events in patients with cirrhosis
  • #VisualAbstract: Lactated Ringer’s Solution Does Not Improve Outcomes Relative to Normal Saline
  • 2MM: AI Roundup – FDA’s AI Push, Trial Speedups with Real-World Data, Smart Surgical Monitors, and Regulatory Overhaul Begins [July 2nd, 2025]
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.