Surgery Classics

Physician-written reports of landmark surgery studies

The AREDS2: No benefit from additional carotenoid and omega-3-fatty acid supplementation to original AREDS...

1. There was no added benefit observed with adding lutein and zeaxanthin, omega-3-fatty acids (DHA and EPA), or the combination to the original AREDS...

The EVS: Vitrectomy results in better visual outcomes for light-perception patients [Classics Series]

1. In patients with endophthalmitis after recent lens implantation, immediate vitrectomy significantly improved visual outcomes for patients presenting with light-perception visual acuity compared to...

The ONTT: Intravenous steroids lead to faster visual recovery in optic neuritis [Classics Series]

1. In patients with first presentation of optic neuritis, treatment with intravenous methylprednisolone followed by oral prednisone resulted in faster visual recovery when compared...

The AREDS1: Zinc and antioxidant supplementation reduce progression of AMD in high-risk patients [The...

1. In patients with advanced age-related macular degeneration (AMD) in one eye only or intermediate AMD in either eye, zinc and antioxidant supplementation reduced...

The FREEDOM trial: Coronary bypass graft vs. PCI in diabetic patients [Classics Series]

1. In patients with diabetes and multivessel disease, coronary artery bypass grafting (CABG) was shown to be superior to percutaneous coronary intervention (PCI) with...

The POISE 2 trial: Aspirin increases risk of major bleeding after noncardiac surgery [Classic...

1. After noncardiac surgeries, patients treated with aspirin had significantly increased risk of major bleeding compared to those taking placebo. 2. There was no significant...

The EMGT: Reducing intraocular pressure slows progression of glaucoma [Classics Series]

1. Treatment using laser trabeculoplasty and topical betaxolol hydrochloride to reduce intraocular pressure (IOP) is associated with delayed progression of glaucoma 2. Treatment to decrease...

The RE-ALIGN trial: Dabigatran vs. warfarin for mechanical heart valves [Classics Series]

1. In patients with mechanical heart valves, anticoagulation with dabigatran was associated with significantly higher rates of stroke and major bleeding when compared to...

Ceftriaxone vs. norfloxacin for prophylaxis in patients with cirrhosis and gastrointestinal bleeding [Classics Series]

1. In cirrhotic patients who presented with gastrointestinal bleeding, patients treated with ceftriaxone were significantly less likely to develop proved or possible infections when...

The BRIDGE trial: Periprocedural bridging in patients with atrial fibrillation [Classics Series]

1. Patients with atrial fibrillation are often treated with long-term oral anticoagulation, and may require interruption of their anticoagulation for elective surgeries or invasive...
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