• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Infectious Disease

Chlorhexidine and povidone-iodine equally effective for skin antisepsis of open fractures undergoing surgical fixation

byNeel MistryandTeddy Guo
October 25, 2022
in Infectious Disease, Orthopedic Surgery, Surgery
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Povidone-iodine and chlorhexidine were comparable in terms of surgical site infections.

2. 16% of patients in both groups required unplanned operation within 1 year of injury.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Surgical site infections are a common occurrence in individuals with open fractures. Povidone-iodine is often used for pre-surgical antiseptic management in such cases. Many studies have shown superiority of chlorhexidine over iodine although its use in open fractures remains unclear. This randomized trial aimed to compare the effect of aqueous 10% povidone-iodine and aqueous 4% chlorhexidine gluconate on the risk of surgical site infection in patients with an open fracture and undergoing surgical fixation. Primary outcome was surgical site infection within 30 days of a superficial incision and within 90 days of a deep or organ space infection. According to study results, 10% povidone-iodine was comparable to 4% chlorhexidine gluconate for skin antisepsis with regards to occurrence of surgical site infections and unplanned reoperation rates. This study was strengthened by a large sample size with hospitals from various countries, thus increasing its generalizability.

Click to read the study in The Lancet

Relevant Reading: Aqueous chlorhexidine 1% versus 2% for neonatal skin antisepsis: a randomised non-inferiority trial

In-depth [randomized-controlled trial]: Between Apr 8, 2018, and Jun 8, 2021, 3619 patients were screened for eligibility across 14 hospitals in Canada, Spain, and the USA. Included were those ≥18 years with an open extremity fracture treated via surgical fixation. Altogether, 1638 patients (828 to povidone-iodine and 810 to chlorhexidine gluconate) were included in the primary analysis. The mean age of patients was 44.9 years (standard deviation [SD] 18.0) with the majority (62%) being male. The primary outcome of surgical site infection was comparable in the povidone-iodine and chlorhexidine groups (7% each, odds ratio [OR} 1.11, 95% confidence interval [CI] 0.74-1.65, p=0.61). Moreover, an equal proportion of patients in either group (17%) had an unplanned reoperation within 1 year of injury (OR 1.08, 95% CI 0.81-1.46, p=0.59). Overall, findings from this study suggest that 10% povidone-iodine and 4% chlorhexidine gluconate are comparable for antiseptic prophylaxis of surgical open fractures.

RELATED REPORTS

High-dose exercise therapy is not superior to low-dose exercise therapy for knee osteoarthritis

#VisualAbstract: Aspirin thromboprophylaxis noninferior to low-molecular-weight heparin in patients with fractures

#VisualAbstract: Thromboprophylaxis with aspirin is non-inferior to low-molecular-weight heparin in preventing death for patients with orthopedic trauma

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: antisepticantiseptic interventionsChlorhexidinefractureopen fractureorthopedic surgeryprovidone-iodinesurgical site infections
Previous Post

Higher blood pressure targets do not improve outcomes in comatose patients

Next Post

#VisualAbstract: Continued enzalutamide after progression of metastatic prostate cancer improves progression-free survival

RelatedReports

Physical therapy reduces pain in adults with knee osteoarthritis
Chronic Disease

High-dose exercise therapy is not superior to low-dose exercise therapy for knee osteoarthritis

February 3, 2023
#VisualAbstract: Aspirin thromboprophylaxis noninferior to low-molecular-weight heparin in patients with fractures
StudyGraphics

#VisualAbstract: Aspirin thromboprophylaxis noninferior to low-molecular-weight heparin in patients with fractures

February 2, 2023
#VisualAbstract: Thromboprophylaxis with aspirin is non-inferior to low-molecular-weight heparin in preventing death for patients with orthopedic trauma
StudyGraphics

#VisualAbstract: Thromboprophylaxis with aspirin is non-inferior to low-molecular-weight heparin in preventing death for patients with orthopedic trauma

January 24, 2023
Type 2 diabetes associated with reduction in disability-free life years
Chronic Disease

Metformin use in Type 2 Diabetes associated with decreased risk of joint replacement

January 16, 2023
Next Post
#VisualAbstract: Continued enzalutamide after progression of metastatic prostate cancer improves progression-free survival

#VisualAbstract: Continued enzalutamide after progression of metastatic prostate cancer improves progression-free survival

Strict tobacco licensing laws linked to reduced adolescent smoking initiation

Financial incentives effective in increasing smoking cessation rates in the UK

Wound surgical device found ineffective at infection control: ROSSINI Trial

Oxygenation strategies inconsequential in comatose survivors of cardiac arrest

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Concordance of diagnosis of autism spectrum disorder made by pediatricians vs multidisciplinary specialist teams
  • Cystatin C-based equation without race or sex improves accuracy of GFR estimation
  • #VisualAbstract: Aldosterone synthase inhibition reduced systolic blood pressure in patients with treatment-resistant hypertension
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options