• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Deterioration of left ventricular ejection fraction to mid-range ejection fraction associated with increased mortality and cardiovascular events

byBrian DoughertyandAlex Chan
June 22, 2020
in Cardiology, Chronic Disease
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

RELATED REPORTS

Catheter ablation reduces rates of persistent atrial fibrillation and atrial tachyarrhythmia

Empagliflozin use is associated with slower progression of chronic kidney disease

Torsemide not associated with significant difference in all-cause mortality over 12 months compared to furosemide – The TRANSFORM-HF randomized clinical trial

1. Heart failure patients whose EF deteriorated from ≥50% to between 40% and 50% were at an increased risk of mortality and cardiovascular events

Evidence Level Rating: 2 (Good)

Clinicians use left ventricular ejection fraction (LVEF) to guide treatment of heart failure (HF). Patients with HF are commonly divided into two separate and clinically distinct cohorts, those with an EF <40% having “heart failure with reduced ejection fraction” (HFrEF) and those with an EF ≥50% having “heart failure with persevered ejection fraction” (HFpEF). This categorization, however, fails to account for patients with an EF between 40% and 50%, sometimes classified as having “heart failure with mid-range ejection fraction” (HFmrEF). The aim of this study was to determine future risk of cardiovascular events based on a prior transition into the HFmrEF group, either by reduction or increase in EF from a previous measurement. Primary outcomes included all-cause mortality, cardiovascular mortality, and all-cause hospitalization, among others. Using health records from the UC San Diego Health System, 448 patients with HFmrEF were identified and followed over an additional two years to track outcomes. 157 patients (M [SD] age = 63.8 [8.1] years, 63.7% male, 54.7% white) improved, 67 patients (M [SD] age = 66.6 [9.8] years, 75.0% male, 64.0% white) remained stable, and 224 patients (M [SD] age = 70.9 [9.5] years, 56.3% male, 62.5% white) deteriorated with regards to their EF prior to inclusion. A 1.34-fold increase in the risk of combined all-cause mortality and hospitalization was seen in the deteriorated group (p = 0.03). The deteriorated group was also at a significantly increased risk of cardiovascular death or hospitalization for HF (HR 1.71, 95% CI 1.08 to 2.50, p = 0.02). Both findings were consistent after adjusting for age, sex, and comorbidity. In contrast, there was no significant difference in risk for any of the primary outcomes between patients in the improved and stable groups even after adjustment. Overall, this study suggests that the directional change of EF in HFmrEF patients has implications for future clinical course and could be used to guide and tailor therapy.

Click to read the study in JAMA Cardiology

©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: cardiologyheart failure
Previous Post

#VisualAbstract: Randomized Trial of Lactin-V to Prevent Recurrence of Bacterial Vaginosis

Next Post

2 Minute Medicine Rewind June 22, 2020

RelatedReports

β-blockers linked to improved survival in preserved ejection fraction heart failure
Cardiology

Catheter ablation reduces rates of persistent atrial fibrillation and atrial tachyarrhythmia

January 27, 2023
Fish oil and aspirin did not reduce arteriovenous fistula failure: The FAVOURED trail
Cardiology

Empagliflozin use is associated with slower progression of chronic kidney disease

January 26, 2023
Radiation dose associated with increased heart disease in Hodgkin lymphoma survivors
Cardiology

Torsemide not associated with significant difference in all-cause mortality over 12 months compared to furosemide – The TRANSFORM-HF randomized clinical trial

January 24, 2023
Remote patient monitoring did not reduce heart failure readmissions: The BEAT-HF trial
Cardiology

Clinical decision-making strategy improves acute heart failure outcomes

January 12, 2023
Next Post

2 Minute Medicine Rewind June 22, 2020

#VisualAbstract: In Utero Antidepressants and Neurodevelopmental Outcomes in Kindergarteners

#VisualAbstract: In Utero Antidepressants and Neurodevelopmental Outcomes in Kindergarteners

Quick Take: Gentamicin compared with ceftriaxone for the treatment of gonorrhoea (G-ToG)

Cholesterol metabolism by uncultured human gut bacteria influences host cholesterol level

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • BNT162b2 booster is safe and reduces COVID-19 transmission in older adults
  • Bisphosphonates, denosumab, abaloparatide, teriparatide, and romosozumab reduce postmenopausal fracture risk
  • Epstein-Barr viral load monitoring reduces risk of post-liver transplant lymphoproliferative disease
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options