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EvidencePulse™ by 2 Minute Medicine 2026 evidence scan 3 reports You asked top stroke trials 2026 Synthesizing medical evidence... Top 2026 stroke trial results: OCEANIC — ischemic stroke: 6.2% vs 8.4% OPTION* — mRS 0–1: 43.6% vs 34.2% ORIENTAL* — mRS 0–2: 58.6% vs 46.6% *Higher sICH in intervention arms Participants randomizedN OCEANIC 12,327 OPTION 570 ORIENTAL 564 Ask about guidelines or landmark trials... ↑ Try EvidencePulse™ Ask the evidence.
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Home All Specialties Chronic Disease

A mobile progressive muscle relaxation program may reduce migraine-related disability

byAlex XiangandSimon Pan
January 13, 2026
in Chronic Disease, Emergency, Neurology
Reading Time: 2 mins read
Migraines associated with an increased risk of cardiovascular events in women
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1. Among adults presenting to the emergency department (ED) with migraine, a smartphone-based progressive muscle relaxation (PMR) program significantly reduced migraine-related disability compared with usual care.

Evidence Rating Level: 1 (Excellent)

Migraine is a common cause of ED visits, but over half of these patients do not have a prior migraine diagnosis and preventive management is rarely initiated at discharge. This 2-group parallel-group randomized control trial evaluated whether a smartphone-based app (RELAXaHEAD) could improve patient-reported migraine outcomes. 94 patients (median age 33 years, 82.6% female) were randomized in a 1:1 fashion to use RELAXaHEAD as a symptom-reporting diary and PMR management vs. as a symptom-reporting diary alone. Patients in the PMR group completed a 5-minute deep-breathing session, a 6-minute PMR session (brief), a 12.5-minute PMR session (full), and an 8.5-minute muscle scan session for a minimum of 60 days during the 90-day treatment period. Patients using PMR had a significantly greater reduction in migraine-related disability (mean change −25.1 vs +6.9; p = 0.01), as measured by the migraine disability assessment. No significant differences were seen in migraine-specific quality of life (MSQv2 questionnaire) or monthly headache days. Overall, app-based PMR reduced migraine-related disability following ED discharge and represents a feasible, low-cost behavioral intervention for migraine management.

Click here to read this study in JAMA Network Open

Image: PD

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