Tag: AIDS

1. For patients with cryptococcal meningitis and AIDS not previously treated with antiretrovirals, survival was better in the group starting antiretrovirals 5 weeks after diagnosis (delayed) vs. the group starting antiretrovirals 1 week after diagnosis (early).  Evidence Rating Level: 1 (Excellent)  Study Rundown: Cryptococcal infection begins in the lungs, but often...

Image: PD  1. HIV co-receptor CCR5 expression was reduced in endometrial and cervical T-cells following hormonal intrauterine device (IUD) insertion.  2. T-cell activation was decreased in the endometrium of levonorgestrel IUD users but increased in the cervix of copper IUD users.  Evidence Rating Level: 2 (Good) Study Rundown: This study found that IUD...

Image: PD  1. Women who maintained viral load suppression between pregnancies were less likely to vertically transmit HIV to their infant.  2. Women who maintained viral load suppression between pregnancies were more likely to have greater viral load suppression at the time of their 2nd delivery.  Evidence Rating Level: 2 (Good)  Study Rundown:...

Image: PD  1. From a cohort study of patients infected with hepatitis C virus (HCV), those with concurrent human immunodeficiency virus (HIV) infection had a slightly higher rate of hepatic decompensation, particularly those with a lower CD4 count and higher HIV viral load.  Evidence Rating Level: 2 (Good)  Study Rundown:  Concurrent HIV...

Image: PD  1. Patients with HSV-2 treated with the helicase-primase inhibitor, pritelivir, had reduced viral shedding over 28 days when compared to patients treated with placebo.  2. Patients treated with pritelivir also experienced fewer days with symptomatic genital lesions than those treated with placebo.  3. Both viral shedding and days with genital...

Image: PD  1. Among HIV-positive African children being treated with anti-retroviral therapy, continuing rather than stopping prophylactic co-trimoxazole led to less morbidity and mortality.  Evidence Rating Level: 1 (Excellent)  Study Rundown: Antiretroviral therapy (ART) directly antagonizes the human immunodeficiency virus and is therefore the cornerstone of treatment for HIV-positive individuals. However, since...

Image: PD  1. Supplementation with multivitamin plus selenium decreased risk of developing a CD4 cell count of 350/μL in ART-naïve HIV-infected patients.  2. Multivitamin plus selenium supplementation did not increase risk of HIV or health-related adverse events.  Evidence Rating Level: 2 (Good)           Study Rundown:  Despite its known efficacy, access...

Image: PD  1. At 48 weeks, the proportion of patients with an HIV-1 RNA level of less than 50 copies/ml was significantly higher in the dolutegravir regimen group than the standard single-tablet regimen group.  2.  Fewer patients in the dolutegravir group discontinued therapy due to adverse events compared to the standard...