![Reduced neuronal BRCA1 associated with decreased DNA repair in Alzheimer’s disease [PreClinical]](https://www.2minutemedicine.com/wp-content/uploads/2015/12/DNA_Furchen_edited-350x250.png)
Reduced neuronal BRCA1 associated with decreased DNA repair in Alzheimer’s disease [PreClinical]
1. In a pre-clinical study of post-mortem brains of Alzheimer’s disease (AD) patients, there was an isolated depletion of neuronal ...
Tag: Alzheimer’s disease
2 Minute Medicine Rewind September 28 – October 4, 2015
Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer Although docetaxel is currently used, effective second line chemotherapy agents are ...
Cardiovascular risk factors related to brain volume and associated dementia
1. Decreases in total brain volume and within specific regions such as the hippocampus were associated with vascular risk factors ...
Alzheimer disease diagnoses aided by amyloid positive PET scans
1. A meta-analysis of amyloid-b-specific positron emission tomography studies in patients with dementia suggests that amyloid positivity decreases with age ...
Amyloid pathology may be detected decades prior to Alzheimer’s diagnosis
1. In this study, the presence of amyloid in patients without dementia was associated with age, APOE genotype, and presence ...
Amyloid may cause distant cerebral hypometabolism in Alzheimer’s
1. In a longitudinal study of 15 patients with Alzheimer’s disease (AD), regions of isolated cerebral hypometabolism detected by FDG-PET ...
Criminal behavior more associated with frontotemporal dementia than Alzheimer disease
1. There was a greater association between criminality and behavioral variant frontotemporal dementia (bvFTD) than there was between criminality and ...
Nanoparticle delivery of proteasomes may improve Alzheimer’s therapy [Pre Clinical]
1. Nanoparticles loaded with proteasomes, protein complexes that degrade defective proteins, were nontoxic and readily taken up by cells in ...
Increased orexin levels linked with poor sleep quality in Alzheimer Disease
1. In Alzheimer disease (AD), increased cerebrospinal fluid (CSF) orexin levels were associated with diminished sleep quality, and increased cognitive ...
Functional connectivity similar between autosomal dominant and late onset Alzheimer Disease
1. Functional MRI images change in similar ways during the progression of both late-onset Alzheimer disease and autosomal dominant (inherited) ...
