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Home Tag CRISPR

Tag: CRISPR

CRISPR-mediated gene activation rescues obesity caused by haploinsufficiency [PreClinical]

Illumina’s billion cell atlas tries to solve artificial intelligence’s data bottleneck in biology

byDeepti Shroff

January 23, 2026

1. Illumina’s Billion Cell Atlas aims to standardize massive CRISPR perturbation data to make biological response patterns more learnable for ...

2MM: AI Roundup- AI Cancer Test, Smarter Hospitals, Faster Drug Discovery, and Mental Health Tech [May 2nd, 2025]

2MM: AI Roundup – Lilly and NVIDIA’s $1B AI lab, Illumina’s Billion Cell Atlas, AstraZeneca’s Modella deal, and Claude for Healthcare [Jan 19th, 2026]

byDeepti Shroff

January 19, 2026

NVIDIA and Lilly put $1B behind AI as core drug infrastructure During the JPMorgan Healthcare Conference week in mid January ...

The 2 Minute Medicine Podcast Episode 15

The 2 Minute Medicine Podcast Episode 29

byAndrew Cheung, MD MBAand1 others

November 30, 2023

Welcome to the 2 Minute Medicine Podcast, summarizing the latest medical studies, curated and written by practicing physicians. On this ...

CRISPR-mediated gene activation rescues obesity caused by haploinsufficiency [PreClinical]

CRISPR-Cas9 promoting fetal hemoglobin production improves severe sickle cell disease

byNhat Hung (Benjamin) Lamand1 others

September 13, 2023

1. In this randomized controlled trial, infusion of OTQ923 disrupted inhibitory HBG1 and HBG2 promoter regions of the gamma-globin gene. ...

CRISPR-mediated gene activation rescues obesity caused by haploinsufficiency [PreClinical]

CRISPR-mediated gene activation rescues obesity caused by haploinsufficiency [PreClinical]

byRadhika Agarwal

1. Haploinsufficiency of Sim1 or Mc4r in the hypothalamus result in an obesity phenotype in mice and humans. 2. In ...

CRISPR-Cas9 corrects hypertrophic cardiomyopathy gene mutation in human preimplantation embryos [PreClinical]

byCorinne Foleyand1 others

August 29, 2017

1. The gene editing tool CRISPR-Cas9 was used to correct a mutant paternal MYBPC3 allele in human preimplantation embryos. 2. ...

BRAF V600E mutations linked with increased mortality in thyroid cancer

Genome editing using CRISPR-Cas9 could correct fatal metabolic liver disease [PreClinical]

byCorinne Foleyand1 others

February 18, 2016

1. Viral vectors were used to deliver the correct sequence for the ornithine transcarbamylase (OTC) gene, the guide sequence to ...

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