Tag: dialysis

1. The findings of this prospective cohort study suggested poor humoral immune response following a single dose of the BNT162b2 COVID-19 vaccine in the hemodialysis patient population compared to two doses. 2. Based on the findings in this study, the second vaccine dose should not be delayed in patients receiving...
1. Vadadustat was shown to be non-inferior to darbepoetin alfa in cardiovascular safety for patients with anemia and dialysis-dependent chronic kidney disease (DD-CKD). 2. Vadadustat was shown to present comparable efficacy in normalizing hemoglobin concentration compared to darbepoetin alfa in the patient population. Evidence Rating Level: 1 (Excellent) Study Rundown: Chronic kidney...
1. Direct oral anticoagulants may have a superior risk-benefit profile compared to vitamin K antagonists in atrial fibrillation for patients with hemodialysis. Evidence Rating Level: 2 (Good) While direct oral anticoagulants (DOACs) have been shown to have superior risk-benefit profiles over vitamin K antagonists (VKAs) in patients with atrial fibrillation and normal...
1. The standardized seroprevalence of SARS-CoV-2 antibodies in the US population was estimated to be 9.3% with significant regional variation. 2. Higher rates of seropositivity were seen in residents of non-Hispanic Black and Hispanic neighborhoods, as well as neighborhoods in the highest population density quintile. Evidence Rating Level: 3 (Average) Study...
1. Drug-coated balloon angioplasty was superior to standard angioplasty for stenotic lesion treatment in hemodialysis arteriovenous fistulas. 2. Drug-coated balloon angioplasty was shown to be noninferior to standard angioplasty for adverse events. Evidence Rating Level: 1 (Excellent) Study Rundown: Arteriovenous (AV) fistulas are given preference over central venous hemodialysis catheters during hemodialysis...
Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study 1. In patients with confirmed SARS-CoV-2 infection within 7 days before or 30 days after surgery, significant mortality was observed, and perioperative pulmonary complications occurred in more than half the patients. Evidence Rating: 2 (Good) Current...
1. In this retrospective quality improvement cohort study from the United States, a multidisciplinary approach was linked with increased rates of peritoneal dialysis initiation compared with national averages Evidence Rating Level: 2 (Good) Study Rundown: Chronic kidney disease is one of the most prevalent chronic diseases in North America, with enormous...
Chronic kidney disease (CKD)-related anemia is associated with significant morbidity, and remains undertreated worldwide. Adequate treatment of CKD-related anemia is associated with reduced transfusion rates and improved clinical outcomes. Roxadustat is a hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor that stabilizes HIF-alpha subunits, resulting in increased transcriptional activity and functional...
Suicide in older adults living in or transitioning to residential long-term care, 2003 to 2015 It is estimated that by the year 2050, 1 in 5 individuals will be 65 years or older. In addition to the growing number of seniors in North America, the rate of suicide has also...
1. In this retrospective cohort study from Israel, hypertension at the age of 16-19 years old was linked with later-life end stage renal disease (ESRD). 2. The association between adolescent hypertension and ESRD remained after accounting for co-morbid conditions such as obesity, and after excluding those with severe hypertension. Evidence Rating...