Tag: testosterone

1. Men with pedophilic disorder treated with gonadotropin-releasing hormone antagonist degarelix were at significantly lower risk of committing sexual abuse 2 weeks following initial injection, as measured by a composite risk score. Evidence Rating: 1 (Excellent) It is estimated that roughly half of child sexual offenders have pedophilic disorder, defined as...

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial 1. Adults with severe COVID-19 treated with remdesivir had numerically faster time to clinical improvement compared to controls, but the difference was not statistically significant Evidence Rating: 1 (Excellent) Months into declaration of COVID-19 as a pandemic, there still remains...

1. Young male cancer survivors with low-normal serum morning total testosterone benefited from testosterone treatment as a therapeutic option to improve body composition. Evidence Rating: 1 (Excellent) Endocrine dysfunction as a long-term sequelae of cancer and its treatments affect are highly prevalent, affecting up to 50% of adult childhood cancer survivors....

1. In this case-crossover study, use of therapeutic testosterone supplementation in men was linked with an increased short-term risk of venous thromboembolism (VTE). 2. Associated risk of VTE with testosterone therapy was demonstrated in men with and without demonstrated hypogonadism, with a trend towards increased risk of VTE in men...

Breast cancer is the most common cancer seen in females, though it is rare in males. Transgender individuals experience incongruence between the sex assigned to them at birth and their experienced or expressed gender. Within this patient population, there has been an increase in the number of referrals for...

Association between incidence exposure to benzodiazepines in early pregnancy and risk of spontaneous abortion Previous studies have shown that benzodiazepine use in early pregnancy is associated with spontaneous abortion (SA). The association between specific benzodiazepines and the risk of SA, however, has not been investigated. In this nested case-control study...

Assessing the Risks Associated with MRI in Patients with a Pacemaker or Defibrillator Patients with implanted cardiovascular electronic devices, such as pacemakers or defibrillators (ICD), often face safety concerns when requiring MRI images, often excluding these patients from MRI studies. This prospective cohort study, MagSafe Registry, identified 1500 patients with...

1. In this non-randomized, double-blind, placebo-controlled study, men 65 years or older who had unexplained anemia with low serum testosterone had an increase in their measured serum hemoglobin with testosterone replacement. 2. Hemoglobin levels increased with testosterone therapy in patients with explained and unexplained anemia, as well as in non-anemic...

1. This placebo-controlled, double-blind trial showed that in older men (³65 years old) with low measured testosterone, one year of testosterone administration increased volumetric bone mineral density and estimated bone strength in trabecular and peripheral bones. 2. While the significant increase in bone density was a positive finding, the clinical...

1. Raising serum testosterone concentrations of men 65 years of age or older, from moderately low to the mid-normal range for men 19-40 years of age, significantly increased sexual function, activity, desire, and erectile function compared to placebo. 2. The sample sizes were not large enough to draw strong...