Tag: thyroid

1. There was no significant improvement of symptoms associated with subclinical hypothyroidism when subjects aged 80 year or older were given levothyroxine versus the placebo.  Evidence rating: 1 (Excellent) Study Rundown: Levothyroxine is a known treatment for hypothyroid-related symptoms such as fatigue, constipation, depression and others.  However, little is known about...

1. First trimester exposure to anytithyroid drugs (ATDs) was associated with a greater risk of congenital malformations, especially for pregnant women who were given prescriptions for methimazole (MMI) or both MMI and propylthiouracil (PTU). 2. These results suggest that first trimester MMI use should be minimized and that the present...

1. In this prospective cohort study, men and women with TSH levels in the highest tertile lived a few years longer than those in the lowest tertile, and lived more years without cardiovascular disease. 2. This relationship also existed with free T4 levels – the lower the T4 level the...

In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Pembrolizumab versus Ipilimumab in Advanced Melanoma Ipilimumab, an immunomodulator that blocks cytotoxic T-lymphocyte associated protein 4, is often the drug of choice for advanced stage melanoma, however has significant immune-related side...

In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Effect of a Balloon-Expandable Intracranial Stent vs Medical Therapy on Risk of Stroke in Patients With Symptomatic Intracranial Stenosis Intracranial stenosis is a common etiology of stroke, often treated with percutaneous...

1. The US Preventive Services Task Force (USPSTF) found insufficient evidence to evaluate the potential benefits and harms of thyroid dysfunction screening for asymptomatic, non-pregnant adults. 2. Although laboratory testing can reliably identify abnormal TSH levels, there is no consensus on the clinical relevance of such levels in asymptomatic adults. Evidence...

In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Use of and Mortality After Bilateral Mastectomy Compared With Other Surgical Treatments for Breast Cancer in California, 1998-2011 Despite studies showing similar survival for patients with early-stage breast cancer treated with breast-conserving...

Image: CC/Wiki  1. Both methimazole(MMI)/carbimazole (CMZ) and prophylthiouracil (PTU) were associated with birth defects, with differing presentations.  2. Further studies are needed to establish the specific teratogenic effects of different hyperthyroid therapies in pregnancy.  Evidence rating level: 2 (Good) Study Rundown: Hyperthyroidism in pregnant women can lead to maternal and fetal complications, such...

Image: PD 1. Ultrasound (US) follow-up for longer than three years did not yield increased cancer detection after a benign fine-needle aspiration (FNA) of a thyroid nodule.  2. Patients with a benign biopsy who were followed for longer than three years had significantly more ultrasounds and FNAs.  Evidence Rating Level: 2 (Good)  Study...