• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Retracted: Underlying cardiovascular disease associated with increased mortality in COVID-19 patients

byHarsh ShahandDeepti Shroff Karhade
June 16, 2020
in Cardiology, Chronic Disease, Infectious Disease, Pulmonology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

This article has since been retracted by NEJM on 6/11/2020.

This 2MM article summary is left unchanged for historical context.

 

1. Underlying cardiovascular disease was shown to be associated with increased risk of in-hospital death among coronavirus disease 2019 (Covid-19) hospitalized patients.

2. Angiotensin-converting-enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) were not shown to be associated with in-hospital mortality among COVID-19 hospitalized patients.

Evidence Rating Level: 2 (Good)

Study Rundown: Recently, there is a growing recognition of patients with underlying cardiovascular risk may be disproportionately affected by COVID-19. Previous case series studies note cardiac arrhythmias, cardiomyopathy, and cardiac arrest as the terminal events in patients with COVID-19. Furthermore, concerns are mounting of cardiovascular disease medical therapies contributing to the severity of illness in the patient population. As such, this study investigated the relationship between underlying cardiovascular disease and COVID-19 outcomes along with evaluating the association between cardiovascular therapeutics and illness mortality. The study collected patient data from the Surgical Outcomes Collaborative (Surgisphere) capturing COVID-19 infection status, underlying cardiovascular disease, and current cardiovascular medications. The study found underlying cardiovascular disease was independently associated with an increased risk of in-hospital death. The results did not show an increased risk of in-hospital mortality with ACE inhibitor or ARB use. This retrospective study was limited by the geographic patient selection for the study. Majority of the patients for the study came from Europe; however, in the timeframe used for the study, Asia was equally negatively affected by COVID-19 as seen in China and South Korea. Therefore, a better distribution of the geographic location during patient selection would have provided stronger study conclusions. Nonetheless, this study was strengthened by providing statistically analyzed data to confirm previous observations between underlying cardiovascular disease and in-hospital deaths. For physicians, these findings highlight the additional care COVID-19 patients with underlying cardiovascular conditions require to overcome the illness.

RELATED REPORTS

Baricitinib reduces mortality risk in patients hospitalized with COVID-19

Moderate-intensity statin plus ezetimibe is non-inferior to high-intensity statin monotherapy

Dapagliflozin associated with reduced risk of cardiovascular and kidney outcomes irrespective of background use of cardiovascular medications

Click to read the study in NEJM

Relevant Reading: Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China

In-Depth [retrospective cohort]: This observational study retrospectively collected data from 8,910 patients at 169 hospitals in 11 countries from Asia, Europe, and North America. Data were collected from inpatient and outpatient electronic health records, financial records, supply-chain databases, and point-of-care data entry for procedures. Cardiovascular coexisting conditions were collected based on codes from the International Classification of Diseases, 10th Revision, Clinical Modification, and COVID-19 positivity was defined as a laboratory finding confirming SARS-CoV2 infection from high-throughput sequencing or real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) of nasal or pharyngeal swab specimens. Inclusion criteria included: patients with a confirmed positive Covid-19 test, hospitalization between December 20, 2019, to March 15, 2020, and a recorded hospital death (nonsurvivors) or hospital discharge (survivors) as of March 28, 2020. Exclusion criteria included: patients admitted during the time window but still hospitalized on March 15, 2020 and patients who did not have their status of death or discharge recorded by the hospital as of March 28, 2020. The primary outcome was the evaluation between the relationship of preexisting cardiovascular disease and drug therapy with the end point of in-hospital death. Confounding variables including demographic characteristics and coexisting conditions were controlled for during the data analyses. Overall, nonsurvivors were older and more likely to be white and male with a history of current smoking. In regard to preexisting cardiovascular conditions, survivors had a lower prevalence of coronary artery disease (-9.2, 95% confidence interval [CI], -12.8 to -5.7), heart failure (-3.7, 95% CI, -5.8 to -1.8), and cardiac arrhythmias (-3.6, 95% CI, -5.8 to -1.4) compared to nonsurvivors. In regard to medications, survivors more commonly used ACE inhibitors (5.9, 95% CI, 4.3 to 7.5) and statins (2.8, 95% CI, 0.5 to 5.1) compared to nonsurvivors, whereas there was no association between survival and the use of ARBs (-1.2, 95% CI, -3.5 to 1.1). Finally, a multivariable logistic-regression model for independent predictors of in-hospital death was performed. The odds ratios for an in-hospital death with the risk factor of coronary artery disease was 2.70 (95% CI, 2.08 to 3.51), receiving an ACE inhibitor was 0.33 (95% CI, 0.20 to 0.54), and receiving an ARB was 1.23 (95% CI, 0.87 to 1.74). Taken together, the study concluded that underlying cardiovascular disease had an increased risk association with in-hospital death; however, the use of ACE inhibitors or ARBs did not show an increased risk association with in-hospital mortality.

Image: PD

©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: ACE inhibitorsangiotension receptor blocker (ARB)cardiovascular diseaseCoronavirusSARS-CoV-2
Previous Post

Psychological impact of COVID-19 on health care workers in Singapore

Next Post

Decrease in influenza transmission with COVID-19 interventions in Hong Kong

RelatedReports

Decreased expression of nasal ACE2 may be correlated with lower prevalence of COVID-19 in children
Chronic Disease

Baricitinib reduces mortality risk in patients hospitalized with COVID-19

August 11, 2022
2 Minute Medicine Rewind October 12 – 19, 2014
Cardiology

Moderate-intensity statin plus ezetimibe is non-inferior to high-intensity statin monotherapy

August 10, 2022
Rilonacept may lower pericarditis recurrence in patients with relapsing pericarditis
Cardiology

Dapagliflozin associated with reduced risk of cardiovascular and kidney outcomes irrespective of background use of cardiovascular medications

July 28, 2022
Medical vaccine exemptions increase after elimination of nonmedical exemptions
Infectious Disease

Effectiveness of second dose of COVID-19 vaccines over a 6 month period

July 26, 2022
Next Post
Live attenuated vaccine less effective in recent influenza season

Decrease in influenza transmission with COVID-19 interventions in Hong Kong

Policy statement outlines recommendations on management of youth involved in the justice system during COVID-19 pandemic

Policy statement outlines recommendations on management of youth involved in the justice system during COVID-19 pandemic

Artificial-intelligence, deep-learning algorithm identifies papilledema from fundus photographs

Artificial-intelligence, deep-learning algorithm identifies papilledema from fundus photographs

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Combined genetic testing of cardiomyopathies and arrhythmias increases diagnostic yield to inform patient management
  • Provision of 1-year mortality data for patients hospitalized with heart failure does not influence clinical decision-making – The REVEAL-HF trial
  • Genetic risk for hemochromatosis associated with abnormal iron deposition localized to motor circuits of the brain
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.