• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home StudyGraphics

#VisualAbstract: Subcutaneous casirivimab and imdevimab reduced symptomatic COVID-19 infection among asymptomatic positive individuals

byMinjee Kim
January 27, 2022
in StudyGraphics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Close household contacts of SARS-CoV-2-infected individuals, who were asymptomatic and positive on RT-qPCR, had a significantly reduced risk of progression to symptomatic infection if treated with subcutaneous casirivimab and imdevimab compared to placebo.

2. The length of high viral load and duration of symptoms among those who became symptomatic were significantly reduced among casirivimab and imdevimab-treated participants.

Evidence Rating Level: 1 (Excellent)

Study Rundown: There is high demand during the COVID-19 pandemic to discover ways of slowing the spread and reducing infection rates. Casirivimab and imdevimab are monoclonal antibodies that bind the SARS-CoV-2 spike protein and prevent the entry of the virus into the body. This phase 3 randomized clinical trial investigated whether subcutaneous casirivimab and imdevimab can reduce progression to symptomatic SARS-CoV-2 infection among baseline asymptomatic close household contacts of infected individuals. This trial was conducted between July 13, 2020, and January 28, 2021, at 112 United States sites. Participants were randomized to receive one dose of casirivimab and imdevimab (n= 158) or placebo (n= 156) within 96 hours of the infected individual’s positive SARS-CoV-2 test. The primary outcome was the proportion of close contact participants who had a positive RT-qPCR result at baseline or within 28 days and developed signs and symptoms of COVID-19 within 14 days of the positive test result. Subcutaneous casirivimab and imdevimab significantly reduced the risk of symptomatic infection within 14 days of a positive RT-qPCR test compared to placebo (29/100 [29.0%] vs. 44/104 [42.3%]; odds ratio [OR]: 0.54 [95% CI: 0.30-0.97]; p= 0.04). Among symptomatic participants, the duration of symptoms was reduced by an average of 5.6 days in the treatment group compared to placebo (21.7 days vs 27.3 days; p= 0.03). Furthermore, the number of weeks with a high viral load (defined as >4 log10 copies/mL) in nasopharyngeal swab samples was significantly reduced among treated patients (489.6 weeks vs. 811.9 weeks per 1000 participants; p= 0.001). Overall, subcutaneous treatment with casirivimab and imdevimab demonstrated significantly reduced progression to symptomatic SARS-CoV-2 infection among asymptomatic, infected, close household contacts. Notably, this trial was conducted before widespread vaccination and onset of variants, such as Delta and Omicron; therefore, further studies are required to elucidate whether these results are consistent during different phases of the pandemic.

Click to read the study in JAMA

RELATED REPORTS

Worsening kidney function observed following SARS-CoV-2 infection in children

Hospital-onset antimicrobial resistance increased during COVID-19 pandemic

Increased blood–urea–nitrogen-to-albumin ratio associated with increased mortality in coronavirus disease

Click to read an accompanying editorial in JAMA

Relevant Reading: Subcutaneous REGEN-COV antibody combination to prevent COVID-19

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: #covid transmissionasymptomatic covidasymptomatic COVID progressionasymptomatic covid transmissioncasirivimabcasirivimab and imdevimabclose household COVID contactscovidCOVID contactsCOVID-19imdevimabSARS-CoV-2symptomatic covid infection
Previous Post

Wellness Check: Exercise

Next Post

Shorter antibiotic course effective in children with community acquired pneumonia

RelatedReports

Being overweight and obese associated with increased incidence of chronic kidney disease
Chronic Disease

Worsening kidney function observed following SARS-CoV-2 infection in children

May 23, 2025
High risk of complications, but low mortality among children with MRSA bacteremia
Infectious Disease

Hospital-onset antimicrobial resistance increased during COVID-19 pandemic

April 28, 2025
Novel coronavirus identified from patients with pneumonia in Wuhan, China
Hematology

Increased blood–urea–nitrogen-to-albumin ratio associated with increased mortality in coronavirus disease

February 10, 2025
American Academy of Pediatrics recommends standards for adverse event disclosures
Weekly Rewinds

2 Minute Medicine Rewind February 10, 2025

February 10, 2025
Next Post
Prescription of antibiotics for acute respiratory infections increasing

Shorter antibiotic course effective in children with community acquired pneumonia

#VisualAbstract: Melflufen plus dexamethasone showed superior progression-free survival over standard of care in multiple myeloma refractory to lenalidomide

#VisualAbstract: Melflufen plus dexamethasone showed superior progression-free survival over standard of care in multiple myeloma refractory to lenalidomide

Risk of myocarditis after receiving mRNA-based COVID-19 vaccines

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Reductions in pain catastrophizing are associated with improvements in emotional functioning
  • Repeated medial branch blocks do not improve pain outcomes for thermal radiofrequency ablation
  • Early screening for emotional and cognitive issues may improve psychiatric outcomes for stroke patients
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.