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EvidencePulse™ by 2 Minute Medicine 2026 evidence scan 3 reports You asked top stroke trials 2026 Synthesizing medical evidence... Top 2026 stroke trial results: OCEANIC — ischemic stroke: 6.2% vs 8.4% OPTION* — mRS 0–1: 43.6% vs 34.2% ORIENTAL* — mRS 0–2: 58.6% vs 46.6% *Higher sICH in intervention arms Participants randomizedN OCEANIC 12,327 OPTION 570 ORIENTAL 564 Ask about guidelines or landmark trials... ↑ Try EvidencePulse™ Ask the evidence.
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Home All Specialties Neurology

Brain injuries linked with increased military suicide risk

byAndrew Bishara
May 19, 2013
in Neurology, Psychiatry
Reading Time: 3 mins read
Brain injuries linked with increased military suicide risk
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 Image: PD

1. Service members who had multiple traumatic brain injuries (TBIs) were at greater suicide risk than those who had zero or one TBI.

2.  Among service members with multiple TBIs, there was a positive relationship between depression severity and suicide risk.

Evidence Rating Level: 3 (Fair)

Study Rundown: This study found that military personnel who suffered multiple TBIs were at greater risk for suicide and might be particularly vulnerable to suicide if depressed. Given that suicide is the second leading cause of death among service members, these results suggest that healthcare providers treating military patients should discuss past TBI history, particularly if patients exhibit signs of depression. Strengths of this investigation include the use of validated questionnaires to determine psychological symptom severity, as well as clinical interview to determine the number of lifetime TBIs. However, the study may have limited generalizability because of its size (n=161), primarily male population (93%), and location (Iraq combat zone). Future studies might employ a prospective design, enrolling a military cohort without any history of TBIs and better accounting for preexisting mental health issues.

Click to read the study in JAMA Psychiatry

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In-Depth [cross-sectional study]: This study examined the relationship between TBIs and psychological problems in 161 participants based in Iraq (157 US military personnel, 4 civilian contractors; average age 27 years). Eligible participants were referred for diagnosis and care of a possible TBI over a 6-month period in 2009. Participants self-reported suicide ideation, depression, post-traumatic stress disorder, and concussion symptoms through questionnaires and received clinical examination and interview to determine number of lifetime TBIs. Depression severity was measured using the Behavioral Health Measure depression scale.

Compared to participants with 0-1 TBIs, participants with ≥2 TBIs were at greater suicide risk (p=0.03). For service members with multiple TBIs, suicide risk increased as depression severity increased (p=0.04). More lifetime TBIs were associated with more severe depression, post-traumatic stress disorder, and TBI symptoms.

By Caroline Huang and Marc Succi

More from this author: Ethnic disparities in HPV 16/18-positive high-grade cervical lesions, Exercise program does not reduce depression in the elderly, Integrated 2D/3D mammography improves breast cancer detection, One third of breast cancer survivors report pain 5-7 years after treatment, Varenicline reduces post-quit smoking relapses

© 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. Content is produced in accordance with fair use copyrights solely and strictly for the purpose of teaching, news and criticism. No benefit, monetary or otherwise, is realized by any participants or the owner of this domain. 

Tags: brain injuryClinical trialshealthmilitarymilitary serviceneurologypsychiatrysuicidetraumatic brain injury
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