Tag: idiopathic pulmonary fibrosis

1. In patients with idiopathic pulmonary fibrosis (IPF) and a low diffusion capacity for carbon dioxide (DLCO), the addition of sildenafil to a treatment regimen of nintedanib did not improve quality of life scores after 12 weeks compared to treatment with nintedanib and a placebo. 2. Dyspnea symptoms did not...
1. The use of recombinant human pentraxin 2 vs placebo resulted in a slower decline in lung function over 28 weeks for patients with idiopathic pulmonary fibrosis. 2. No significant treatment differences were observed in total lung volume, parenchymal features on high resolution CT, or diffusion capacity of carbon monoxide...
1. An enzyme involved in thyroid hormone activation was found to be elevated in patients with pulmonary fibrosis. 2. Following the treatment of various mouse models of pulmonary fibrosis with thyroid hormone, mitochondrial function improved and signs of fibrosis decreased. Evidence Rating Level: 2 (Good) Study Rundown: Idiopathic pulmonary fibrosis (IPF) is...
  1. A gallium-labeled, collagen-binding peptide (68Ga-CBP8) specifically identified fibrotic tissue via positron emission tomography (PET) imaging in two mouse models of idiopathic pulmonary fibrosis (IPF). 2. Changes in 68Ga-CBP8 uptake by fibrotic lungs reflected diminished disease progression in mice treated with an antifibrotic therapeutic, thereby demonstrating the potential utility...
1. Double-lung transplant is associated with lower 5-year mortality rates than single-lung transplant in patients with idiopathic pulmonary fibrosis (IPF). 2. There is no difference in 5-year mortality and median graft survival between single and double-lung transplants in patients with chronic obstructive pulmonary disease (COPD). Evidence Rating Level: 2 (Good)  ...
Image: PD/ Fibrotic lung 1. Ambrisentan is ineffective in delaying disease progression in idiopathic pulmonary fibrosis (IPF). 2. Compared to placebo, Ambrisentan is associated with increased risk of disease progression and respiratory hospitalization. Evidence rating level: 1 (Excellent) Study rundown: Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive form of fibrotic interstitial lung disease...