Tag: major depressive disorder (MDD)

1. Psilocybin treatment was shown not to report significantly improved self-reported depression scores compared to escitalopram treatment in patients with major depressive disorder. 2. Secondary outcomes of other mental health scales may have improved with psilocybin treatment but could not be directly compared to escitalopram treatment. Evidence Rating Level: 1 (Excellent) Study...

1. Mood homeostasis, or the preferential ability to engage in adequate mood-modifying behaviors, is associated with mean mood and history of depression. 2. Individuals with low mean mood had significantly lower mood homeostasis scores than those with higher mean moods. This relationship was also found among those who had a...

Viral Load Dynamics and Disease Severity In Patients Infected With SARS-CoV-2 In Zhejiang Province, China, January-March 2020: Retrospective Cohort Study 1. Stool samples demonstrated significantly longer duration of positive viral load than both respiratory and serum samples. 2. Length of positive RNA detection was associated with disease duration with a peak...

1. In this modeling study comparing the cost-effectiveness of cognitive behavioral therapy (CBT) with second-generation antidepressants (SGA) for initial treatment of depression, neither strategy provided consistently superior economic outcomes. However, over the long term, it is possible that increased use of CBT may generate significant savings. 2. Given patient preferences...

1.  In this randomized controlled trial, patients with Major depressive disorder with psychotic features who were stable on olanzapine and sertraline showed higher relapse upon discontinuation of olanzapine than those who remained on both drugs over 36 weeks. 2. Patients who remained on both drugs had more weight gain but...

1.  In this randomized controlled trial, patients with Major depressive disorder with psychotic features who were stable on olanzapine and sertraline showed higher relapse upon discontinuation of olanzapine than those who remained on both drugs over 36 weeks. 2. Patients who remained on both drugs had more weight gain but...

1. In this systematic review and meta-analysis, there were significantly lower cognitive functioning scores for those who were first-degree relatives of patients with a history of major depressive disorder (MDD). 2. The lower scores for cognitive testing were demonstrated across multiple domains of cognition including IQ, verbal intelligence, perceptual intelligence,...