Tag: Ulcerative Colitis

1. In this randomized controlled trial, patients who received a donor fecal microbiota transplant (FMT) had a higher rate of steroid-free remission at 8-weeks than those who a received autologous FMT. 2. Donor FMT was also associated with better clinical response and clinical remission. Evidence Rating Level: 1 (Excellent) Study Rundown: Ulcerative colitis...

1. In this randomized controlled trial, patients who received a donor fecal microbiota transplant (FMT) had a higher rate of steroid-free remission at 8-weeks than those who a received autologous FMT. 2. Donor FMT was also associated with better clinical response and clinical remission. Evidence Rating Level: 1 (Excellent) Study Rundown: Ulcerative...

1. Repeated gastrointestinal infections in mice, in this case Salmonella enterica Typhimurium (ST), caused intestinal tissue inflammation which escalated with repeated infections. 2. Increased turnover of intestinal alkaline phosphatase (IAP), related to increased endogenous neuraminidase activity among duodenal enterocytes, was found to be associated with inflammatory bowel disease (IBD). The...

1. In this retrospective cohort study, inflammatory bowel disease (IBD) patients on anti-tumor necrosis factor (TNF) agents or thiopurines had a higher rate of developing lymphoma compared to non-exposed IBD patients. 2. The combination of both anti-TNF agents and thiopurines resulted in a higher risk or lymphoma than either alone. Evidence...

1. This systematic review and meta-analysis demonstrated the high diagnostic performance of magnetic resonance (MR) enterography in the diagnosis of active inflammation in pediatric inflammatory bowel disease (IBD). 2. There was substantial heterogeneity, some of which was unexplained, in the original studies which limits the reliability of this study. Evidence Rating...

1. Patients with active ulcerative colitis who failed prior treatment achieved significantly greater remission of disease and mucosal healing compared to those treated with placebo. 2. Remission of ulcerative colitis symptoms over 1 year was significantly greater for patients who initially responded to tofacitinib and continued therapy compared to patients...

1. Patients receiving 1mg of the lymphocyte-suppressing agent Ozanimod showed significant clinical improvement in ulcerative colitis (UC) symptoms compared to placebo at 8 weeks and 32 weeks after treatment was started. 2. Absolute blood lymphocyte counts were reduced in patients taking 0.5mg and 1mg doses of Ozanimod at 8...

1. In this matched cohort study, patients with advanced ulcerative colitis who underwent elective colectomy had improved overall survival compared to matched patients who were managed with long-term medical therapy. 2. Sensitivity analysis showed that age greater than 50 was particularly associated with a mortality benefit from surgery compared to...

Originally published by Harvard Health. What Is It? Ulcerative colitis is an inflammatory disease. It usually begins in the rectum, then worsens to involve some or all of the large intestine. Ulcerative colitis is a lifelong condition. Ulcerative colitis may begin with a breakdown in the lining of the intestine. The inside of...

Image: PD  In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease Vedolizumab is a humanized monoclonal antibody targeting α4β7 integrin, which modulates gut lymphocyte...